202276-17-3Relevant academic research and scientific papers
Rotational features of carbon-nitrogen bonds in axially chiral o-tert- butyl anilides and related molecules. Potential substrates for the 'prochiral auxiliary' approach to asymmetric synthesis
Curran, Dennis P.,Hale, Gregory R.,Geib, Steven J.,Balog, Aaron,Cass, Quezia B.,Degani, Ana Luiza G.,Hernandes, Marcelo Z.,Freitas, Luiz Carlos G.
, p. 3955 - 3975 (1997)
A new strategy for asymmetric induction termed the 'prochiral auxiliary' approach is introduced. Reactions of acylating agents with prochiral N- methyl-o-tert-butyl aniline provide anilides that are axially chiral by virtue of restricted rotation about th
