Rotational features of carbon-nitrogen bonds in axially chiral o-tert- butyl anilides and related molecules. Potential substrates for the 'prochiral auxiliary' approach to asymmetric synthesis

Article abstract of DOI:10.1016/S0957-4166(97)00599-5

A new strategy for asymmetric induction termed the 'prochiral auxiliary' approach is introduced. Reactions of acylating agents with prochiral N- methyl-o-tert-butyl aniline provide anilides that are axially chiral by virtue of restricted rotation about th