20230-73-3

Upstream product

• 64481-62-5 methyl D-apiofuranoside 
• 26544-34-3 apiin 
• 1192501-86-2 3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 
• 1192501-87-3 3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-[β-D-apiosyl-(1->3)]-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 
• 1227937-35-0 4,6-decadiyne-1-O-β-D-apiofuranosyl-(1->6)-β-D-glucopyranoside 
• 1275615-11-6 8-C-(2-O-β-D-apiofuranosyl)-β-D-glucopyranosyl apigenin 
• 1267635-92-6 (3S,5R,6S,7E,9R)-7-megastigmene-3,6,9-triol 3-O-β-D-(2'-O-β-D-apiofuranosyl)glucopyranoside 
• 1667763-77-0 6-C-β-D-apiofuranosyl-(1→ 4)-β-D-galactopyranosylnaringetol 

Downstream Products

• 10592-17-3 (3S)-2-hydroxymethylbutane-1,2,3,4-tetrol 
• 6013-71-4 N-benzylphenylhydrazone of D-apiose 

Relevant academic research and scientific papers

Chemical constituents of Miliusa balansae leaves and inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells

Abstract Methanolic extract of Miliusa balansae Finet et Gagnep exerts an anti-inflammatory effect via inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Three new megastigmane glycosides, milbasides A-C (1-3), together with fifteen known compounds (4-18), were isolated from the active fraction. Their chemical structures were elucidated using extensive spectroscopic analyses, including 1D and 2D NMR, HR ESI MS, and CD analysis, as well as comparison with previously reported data. Compounds 1-3, 11 and 14 (20.0 μM) showed potent inhibitory activities with inhibition values of 98.5 ± 1.6%, 90.9 ± 7.8%, 84.8 ± 3.5%, 91.5 ± 8.7%, and 91.8 ± 2.7%, respectively. Our results suggest that megastigmane glycosides from M. balansae leaves may be used to treat inflammatory diseases.

Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs

A methanol extract of the twigs of Cinnamomum cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A-C (11-13), together with 10 known compounds (1-10). The structures of

Identification of compounds from the water soluble extract of cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells

The difficulty of diabetic nephropathy (DN) treatment makes prevention the best choice. Cinnamomum cassia barks, known as Chinese cinnamon or Chinese cassia, is one of the most popular natural spices and flavoring agents in many parts of the World. Since

A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity

Two new compounds, piperoside (1) and isoheptanol 2(S)-O-β-d- xylopyranosyl (1→6)-O-β-d-glucopyranoside (11), along with 10 known compounds 3,4-dihydroxyallylbenzene (2), 1,2-di-O-β-d-glucopyranosyl-4- allylbenzene (3), tachioside (4), benzyl-O-β-d-glucopyranoside (5), icariside F2 (6), dihydrovomifoliol-3′-O-β-d- glucopyranoside (7), isopropyl O-β-d-glucopyranoside (8), isopropyl primeveroside (9), n-butyl O-β-d-glucopyranoside (10), isoheptanol 2(S)-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (12), were isolated from the leaves of Piper retrofractum. Their structures were determined from 1D-NMR, 2D-NMR, and HR-ESI-MS spectral, a modified Mosher's method, and comparisons with previous reports. All of the isolated compounds showed modest α-glucosidase inhibitory (4.60 ± 1.74% to 11.97 ± 3.30%) and antioxidant activities under the tested conditions.

Phenolic glycosides from sugar maple (Acer saccharum) bark

Four new phenolic glycosides, saccharumosides A-D (1-4), along with eight known phenolic glycosides, were isolated from the bark of sugar maple (Acer saccharum). The structures of 1-4 were elucidated on the basis of spectroscopic data analysis. All compounds isolated were evaluated for cytotoxicity effects against human colon tumorigenic (HCT-116 and Caco-2) and nontumorigenic (CCD-18Co) cell lines.

Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and α-glucosidase

Abietane derivatives, bungnates A, B, 15-dehydrocyrtophyllone A and 15-dehydro-17-hydroxycyrtophyllone A, and two phenylethanoid glycosides, bunginoside A and 3″,4″-di-O-acetylmartynoside, together with nine known abietane derivatives and fourteen known phenylethanoid glycosides, were isolated from dried roots of Clerodendrum bungei. Their structures were determined on the basis of detailed spectroscopic analyses and acidic hydrolysis. The absolute configuration of bunginoside A was established from analysis of CD data. Selected compounds were evaluated for inhibitory effects against angiotensin converting enzyme (ACE) and α-glucosidase. 15-Dehydrocyrtophyllone A showed an ACE inhibitory effect, and verbascoside, leucosceptoside A and isoacteoside exhibited strong inhibitory capacity against α-glucosidase.

Crotocascarins I-K: Crotofolane-type diterpenoids, crotocascarin γ, isocrotofolane glucoside and phenolic glycoside from the leaves of croton cascarilloides

From the 1-BuOH-soluble fraction of a methanol (MeOH) extract of the leaves of Croton cascarilloides, crotofolanes: crotocascarins I-K, nor-crotofolane: crotocascarin γ, isocrotofolane glucoside and phenolic glycoside were isolated by a combination of various separation techniques. Their structures were elucidated mainly from the NMR spectroscopic evidence. The structure of crotocascarin K was first elucidated by spectroscopic analysis and then was confirmed by X-ray crystallographic analysis. Its absolute structure was finally determined by the modified Mosher's method. Isocrotofolane glucoside was found to possess a new skeleton, however, its absolute structure remains to be determined.

Four new glycosides from the fruit of Xanthium sibiricum patr.

Four new glycosides, namely 3β-norpinan-2-one 3-O-β-D- apiofuranosyl-(1→6)-β-D-glucopyranoside (1), (6Z)-3-hydroxymethyl-7- methylocta-1,6-dien-3-ol 8-O-β-Dglucopyranoside (2), (6E)-3-hydroxymethyl- 7-methylocta-1,6-dien-3-ol 8-O-β-D-glucopyranoside (3),

Six new steroidal saponins from helleborus thibetanus

Six steroidal saponins, including five spirostanol glycosides, 1 - 5, and one furostanol glycoside 1- sulfonate, 6, previously unknown in nature, together with three known compounds, 7 - 9, were isolated from dried roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive 1D- And 2D-NMR experiments, along with IR and HR-ESI-MS data, as well as the results of acid hydrolysis. Compounds 1 - 5 possessed a C(25)=C(27) bond and were glycosylated at HO-C(1), which was unusual in steroidal saponins.

Chemical constituents isolated from Disporum viridescens leaves and their inhibitory effect on nitric oxide production in BV2 microglial cells

Excessive NO (nitric oxide) has been associated with the pathogenesis of various neurodegenerative diseases including Alzheimer's disease (AD). In our screening system using LPS-activated BV2 microglial cells, the methanolic extract of Disporum viridescen