20231-59-8Relevant academic research and scientific papers
Preparation method of muricholic acid
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Paragraph 0056-0063; 0100-0105, (2019/03/06)
The invention relates to the technical field of drug synthesis, in particular to a preparation method of muricholic acid. According to the preparation method of the muricholic acid, 3[alpha], 6[alpha]-dyhydroxy-5[beta]-cholanic acid are used as raw materials for to be subjected to alkyl esterification, site-3 and site-6 selective oxidation is performed, a bromination reaction is performed, a substitution reaction is performed, site-6 reduction is performed, and hydrolysis is performed to obtain the muricholic acid. The muricholic acid is prepared by the synthetic route, namely 3[alpha], 6[beta], 7[beta]-trihydroxy-5[alpha]-cholanoic acid, a raw material source is wide, and sufficient supply is achieved; and the yield of the muricholic acid obtained by the steps is high and up to 24.5%, andthe muricholic acid is suitable for large-scale preparation and can provide data support and reference for subsequent related researches.
