202336-25-2Relevant academic research and scientific papers
BENZOTHIOPHENE DERIVATIVES AS ESTROGEN RECEPTOR INHIBITORS
-
, (2015/01/16)
A compound of formula (I), or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.
Nucleophilic aromatic substitution on 3-aroyl-2-arylbenzothiophenes. Rapid access to raloxifene and other selective estrogen receptor modulators
Schmid, Christopher R.,Sluka, James P.,Duke, Kristin M.
, p. 675 - 678 (2007/10/03)
Versatile, mild and high yielding methods for nucleophilic aromatic substitution of 2-dialkylamino-1-ethoxides and related nucleophiles on 3- aroyl-2-arylbenzothiophene nuclei are presented. A short synthesis of raloxifene is detailed.
Benzothiophene compounds, and uses formulations thereof
-
, (2008/06/13)
Benzothiophenes, and uses and formulations thereof, are provided by the present invention.
Benzothiophene compounds, and uses and formulations thereof
-
, (2008/06/13)
Benzothiophenes, and uses and formulations thereof, are provided by the present invention. The compounds are of the formula wherein R1and R2are independently -OH, -OCO(C1-C6alkyl), -O(CO)O(C1-C6alkyl), -OCO-Ar, where Ar is phenyl or substituted phenyl, or -O(CO)Ophenyl; and R3is a substituent in the 3 or 4 position of the phenyl ring selected from the group of -H, -Cl, -Br, -CH3, or -CH2CH3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when R1and R2are both hydroxy, R3is not -H, -CH3, or -CH2CH3.
