202347-81-7Relevant articles and documents
Synthesis of enantiomerically pure α-amino acids via chemo- and diastereoselective alkylation of (5S)-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one
Harwood, Laurence M.,Tyler, Simon N. G.,Anslow, A. Susan,MacGilp, Iain D.,Drew, Michael G. B.
, p. 4007 - 4010 (2007/10/03)
(5S)-5-Phenyl-5,6-dihydro-2H-1,4-oxazin-2-one 2 undergoes Lewis acid-mediated chemo- and diastereoselective nucleophilic addition of Grignard reagents to furnish adducts 3 which can be dismantled to allow ready access to enantiomerically pure (S)-α-amino acids 4.
