202467-31-0Relevant academic research and scientific papers
5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
Boes, Michael,Sleight, Andrew J.,Godel, Thierry,Martin, James R.,Riemer, Claus,Stadler, Heinz
, p. 165 - 178 (2007/10/03)
RO-04-6790 (6a) has been identified in a random screen for 5-HT6 receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a log D profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm.
USE OF SULFONAMIDES
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, (2008/06/13)
The present invention is concerned with compounds of formula STR1 wherein Z is a substituted pyridyl group of formula STR2 R. sup.1 is hydrogen, amino, lower alkylamino, lower dialkylamino, lower alkyl, halogen, or trifluoromethyl;R 2 is hydrogen or lower alkyl;R 5 is hydrogen, lower alkyl, lower alkylamino, di-lower alkylamino, lower alkoxy, or halogen;R 6 lower alkylamino, di-lower alkylamino, lower alkoxy, halogen, or CF 3.
