10371-48-9

Basic information

• Product Name: 4,6-dichloro-N-ethylpyriMidin-2-aMine
• Synonyms: 4,6-dichloro-N-ethylpyriMidin-2-aMine
• CAS NO: 10371-48-9
• Molecular Formula: C₆H₇Cl₂N₃
• Molecular Weight: 192.04588
• Mol File: 10371-48-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,6-dichloro-N-ethylpyriMidin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-N-ethylpyriMidin-2-aMine(10371-48-9)
• EPA Substance Registry System: 4,6-dichloro-N-ethylpyriMidin-2-aMine(10371-48-9)

Safety Data

• Hazardous Substances Data: 10371-48-9(Hazardous Substances Data)

Usage

General Description

4,6-dichloro-N-ethylpyriMidin-2-aMine is a chemical compound with the molecular formula C7H9Cl2N5. It is a chlorinated derivative of the organic compound pyrimidine, containing two chlorine atoms and an ethyl group attached to the nitrogen atom at position 6. 4,6-dichloro-N-ethylpyriMidin-2-aMine is used in the synthesis of various pharmaceuticals and agrochemicals. It is known for its antimicrobial and antifungal properties, making it a valuable component in the development of drugs and pesticides. Additionally, it is used as a research reagent in the study of biological processes and pathways.

Upstream product

• 75-04-7 ethylamine 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 
• 3764-01-0 2,4,6-trichloropyrimidine 

Downstream Products

• 202467-31-0 4-amino-N-(6-chloro-2-ethylaminopyrimidin-4-yl)benzenesulfonamide 

Relevant articles and documents

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.

Endowed with anti-viral activity 2-alkylamino-4,6-dihalo pyrimidines

The invention relates to new pyrimidine derivatives endowed with anti-viral activity, to the method for the preparation thereof and to the pharmaceutical compositions containing them. Pyrimidine derivatives of the invention are useful for the treatment of animals and human patients infected with viruses.