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Usage

Uses

Used in Pharmaceutical Synthesis:
4,6-dichloro-N-ethylpyriMidin-2-aMine is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its antimicrobial and antifungal properties make it a valuable component in the development of drugs targeting a range of infections.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4,6-dichloro-N-ethylpyriMidin-2-aMine is employed as a building block for the creation of pesticides. Its antimicrobial and antifungal properties are harnessed to protect crops from diseases and pests, thereby enhancing agricultural productivity.
Used in Research Applications:
4,6-dichloro-N-ethylpyriMidin-2-aMine also serves as a research reagent in the study of biological processes and pathways. Its unique chemical structure allows scientists to investigate its interactions with biological systems, potentially leading to new insights and discoveries in the fields of medicine and biology.

Upstream product

• 75-04-7 ethylamine 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 
• 3764-01-0 2,4,6-trichloropyrimidine 

Downstream Products

• 202467-31-0 4-amino-N-(6-chloro-2-ethylaminopyrimidin-4-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.

Simplified analogues of acyclonucleosides. Synthesis of 6-[N-alkyl-N-(4- hydroxybutyl)amino]pyrimidine derivatives

The synthesis of some 6-alkylaminopyrimidine derivatives bearing a 4- hydroxybutyl chain as sugar mimic is described. These new compounds can be regarded as simplified, ring-opened analogues of purine acyclonucleosides.

Endowed with anti-viral activity 2-alkylamino-4,6-dihalo pyrimidines

The invention relates to new pyrimidine derivatives endowed with anti-viral activity, to the method for the preparation thereof and to the pharmaceutical compositions containing them. Pyrimidine derivatives of the invention are useful for the treatment of animals and human patients infected with viruses.