2025-18-5Relevant academic research and scientific papers
One-pot synthesis of functionalized pyrazolo[3,4-c]pyrazoles by reaction of 2-cyano-N-methyl-acrylamide, aryl aldehyde, and hydrazine hydrate
Asadi, Sara,Alizadeh-Bami, Farzaneh,Mehrabi, Hossein
, p. 238 - 246 (2020/09/11)
A simple and efficient procedure for the synthesis of novel 4-aryl pyrazolo[3,4-c]pyrazol-3(2H)-ones via a one-pot, three-component reaction between 2-cyano-N-methylacetamide, aryl aldehydes, and hydrazine hydrate in the presence of Et3N in DMF is reported. Products are obtained in good yields and their structures are supported by their spectroscopic data and combustion analysis.
Reaction of 3-aryl-2-cyanothioacrylamides with dimethyl acetylenecarboxylate, methyl propiolate, and N-phenylmaleimide
Deryabina,Demina,Belskaya,Bakulev
, p. 2880 - 2889 (2007/10/03)
The reaction of cyanothioacrylamides with dimethyl acetylenedicarboxylate, methyl propiolate, and N-phenylmaleimide was studied. The reaction follows a cycloaddition pathway to give thiopyrans, irrespective of the electronic or spatial effects of the substituents in the thioamide group and in position 3 of the 1-thiabuta-1,3-diene system. The reaction is regio-and stereoselective.
