202584-14-3

Basic information

• Product Name: 1,6-dimethyl-1H-indole-3-carbaldehyde
• Synonyms: 1,6-dimethyl-1H-indole-3-carbaldehyde;1H-Indole-3-carboxaldehyde, 1,6-dimethyl-
• CAS NO: 202584-14-3
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21114
• Mol File: 202584-14-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1,6-dimethyl-1H-indole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-dimethyl-1H-indole-3-carbaldehyde(202584-14-3)
• EPA Substance Registry System: 1,6-dimethyl-1H-indole-3-carbaldehyde(202584-14-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 202584-14-3(Hazardous Substances Data)

Usage

General Description

1,6-dimethyl-1H-indole-3-carbaldehyde is a chemical compound with the molecular formula C11H11NO. It is an aldehyde derivative of indole, a heterocyclic organic compound. This chemical is commonly used as a building block for the synthesis of various pharmaceutical and agrochemical products. It is also used in organic synthesis and in research laboratories as a reagent for the preparation of other chemical compounds. 1,6-dimethyl-1H-indole-3-carbaldehyde has a characteristic indole structure and is known for its mild and pleasant odor. It is a colorless to pale yellow liquid at room temperature and is soluble in various organic solvents.

Upstream product

• 5621-15-8 1,6-dimethyl-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 75-50-3 trimethylamine 
• 50-00-0 formaldehyd 
• 3420-02-8 6-methylindole 
• 4771-49-7 6-methyl-1H-indole-3-carboxaldehyde 
• 74-88-4 methyl iodide 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 

Relevant articles and documents

Yb(OTf)3catalyzed [1,3]-rearrangement of 3-alkenyl oxindoles

A Yb(OTf)3catalyzed [1,3]-rearrangement of 3-alkenyl oxindoles was achieved, affording a variety of multifunctional 3-ylideneoxindoles with good yields andZ/Eselectivities (64%-89% yield, 78?:?22->99?:?1Z/E). Importantly, an operationally simple, one-pot sequential catalytic synthesis of 3-ylideneoxindoles was also developed. Additionally, a cross [1,3]-rearrangement experiment and nonracemic transformation were also carried out, which indicated a concerted rearrangement mechanism of this methodology.

Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes

Reported herein is an effective strategy for oxidative cross-coupling of indoles with various aldehydes. The strategy is based on a two-step transformation via a well-known Mannich-type reaction and a C-N bond cleavage for carbonyl introduction. The key step - the C-N bond cleavage of the Mannich product - was enabled by electrochemistry. This strategy (with over 40 examples) ensures excellent functional-group tolerance as well as late-stage functionalization of pharmaceutical molecules.

Indole-substituted hydrazide derivatives and uses thereof

The invention discloses indole-substituted hydrazide derivatives and a use thereof, concretely relates to novel indole-substituted hydrazide derivatives and a medicinal composition including the abovecompounds, a use of the derivatives and the medicinal composition in the protection of nerve cells, and also relates to a method for preparing the compounds and the medicinal composition, and a use of the compounds and the medicinal composition in the preparation of drugs for treating diseases associated with glutamate excitotoxicity and oxidative stress damage or free radicals, or neurodegenerative diseases, especially the Alzheimer disease.