20261-85-2 Usage
Uses
Used in Pharmaceutical Research:
NSC63925 is used as a research compound for studying the properties of monovalent cation ionophores and their interactions with biological membranes. Its ability to selectively transport specific ions makes it a useful tool in understanding membrane transport mechanisms and ion channel functions.
Used in Immunology:
NSC63925 is used as an immunosuppressive agent for inhibiting T-cell proliferation induced by IL-2. It also suppresses cytokine production at nanomolar levels for IL-2, IL-4, IL-5, and interferon-γ, making it a potential candidate for investigating immune system regulation and developing novel therapeutic strategies for autoimmune and inflammatory diseases.
Used in Antifungal Applications:
NSC63925 is used as an antifungal agent, being a component of a macrotetralide-rich mixture produced by Streptomyces. Its role in inhibiting fungal growth contributes to the development of new antifungal treatments and understanding the mechanisms of action against various fungal pathogens.
Used in Pulmonary Eosinophilia Research:
NSC63925 is used as a therapeutic agent for reducing pulmonary eosinophilia in antigen-challenged mice. This application highlights its potential in studying and treating allergic asthma and other eosinophilic disorders affecting the respiratory system.
in vitro
dinactin inhibited t-cell proliferation induced by il-2, by mab to cd3, and by mabs to cd3 plus α-cd28 with identical dose-response curves. the ic50 was 10–20 ng/ml. dinactin inhibited cytokine production with ic50 values of 10 ng/ml for il-4 and il-5, 30 or 60 ng/ml for interferong or il-2, respectively [3].dinactin inhibited cytokine production through a post-transcriptional mechanism. dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].
references
[1] laprade r, grenier f, pagé-dansereau m, et al. carrier-mediated ion transport in lipid bilayer membranes[j]. canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.[2] silva l j, crevelin e j, souza w r, et al. streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control botrytis cinerea[j]. phytopathology, 2014, 104(12): 1298-1305.[3] umland s p, shah h, jakway j p, et al. effects of cyclosporin a and dinactin on t-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[j]. american journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.
Check Digit Verification of cas no
The CAS Registry Mumber 20261-85-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,6 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 20261-85:
(7*2)+(6*0)+(5*2)+(4*6)+(3*1)+(2*8)+(1*5)=72
72 % 10 = 2
So 20261-85-2 is a valid CAS Registry Number.
InChI:InChI=1/C42H68O12/c1-9-29-21-33-13-17-35(51-33)25(5)39(43)47-24(4)20-32-12-16-38(50-32)28(8)42(46)54-30(10-2)22-34-14-18-36(52-34)26(6)40(44)48-23(3)19-31-11-15-37(49-31)27(7)41(45)53-29/h23-38H,9-22H2,1-8H3/t23-,24-,25-,26-,27+,28+,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+/m0/s1
20261-85-2Relevant academic research and scientific papers
Biosynthesis of the Macrotetrolide Antibiotics; The Incorporation of Carbon-13 and Oxygen-18 Labelled Acetate, Propionate, and Succinate
Ashworth, Doreen M.,Robinson, John A.,Turner, David L.
, p. 1719 - 1728 (2007/10/02)
The biosynthesis of the macrotetrolide antibiotics, in particular nonactin, has been studied using carbon-13 and oxygen-18 enriched acetate and propionate, as well as carbon-13 enriched succinate, in feeding experiments with the producing organism Streptomyces griseus.A protocol is described which allows the separation of derivatives formed from each enantiomer of nonactic and homononactic acids.From a study of the incorporation of the labelled precursors into these derivatives it could be shown that the origins of the carbon and oxygen atoms in each enantiomer are identical.The carbon backbone of nonactic acid is assembled from two acetate, one succinate, and one propionate units, and the C-O bonds at C-8, C-6, and C-1 are derived intact from the primary precursors.Based on these data a new proposal is made to account for the biosynthesis of (+/-)-nonactate, and nonactin, in S. griseus.
