202647-58-3Relevant academic research and scientific papers
New synthetic heparin mimetics able to inhibit thrombin and factor Xa
Petitou, Maurice,Duchaussoy, Philippe,Driguez, Pierre-A,Herault, Jean-P,Lormeau, Jean-C,Herbert, Jean-M
, p. 1155 - 1160 (1999)
Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT HI) binding pentasaccharide prolonged at the non- reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.
Experimental proof for the structure of a thrombin-inhibiting heparin molecule
Petitou, Maurice,Imberty, Anne,Duchaussoy, Philippe,Driguez, Pierre-Alexandre,Ceccato, Marie-Line,Gourvenec, Francoise,Sizun, Philippe,Herault, Jean-Pascal,Perez, Serge,Herbert, Jean-Marc
, p. 858 - 873 (2007/10/03)
Kinetic studies of thrombin inhibition by antithrombin in the presence of heparin have shown that thrombin binds to heparin in a preformed heparin-antithrombin complex. To study the relative position of the thrombin binding domain and the antithrombin bin
