Bioorganic and Medicinal Chemistry Letters p. 1155 - 1160 (1999)
Update date:2022-08-05
Topics:
Petitou, Maurice
Duchaussoy, Philippe
Driguez, Pierre-A
Herault, Jean-P
Lormeau, Jean-C
Herbert, Jean-M
Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT HI) binding pentasaccharide prolonged at the non- reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.
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