202650-96-2

Upstream product

• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 38879-46-8 (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone 
• 104-88-1 4-chlorobenzaldehyde 
• 22278-80-4 4-amino-6-benzyl-3-mercapto-1,2,4-triazine-5(4H)-one 

Relevant academic research and scientific papers

Studies on arylmethyltriazinone derivatives-Part II. Synthesis and antifungal properties of 2-aminomethyl-4-(arylidene)amino-6-arylmethyl-3-mercapto-1, 2,4-triazin-5(4H)-ones

The preparation of twenty new 2-aminomethyl-4-(arylidene)amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)- ones(4) is described. The structural elucidation of all the compounds is carried out on the basis of analytical and spectral data. The newly synthesized compounds are evaluated for their antifungal activity against Candida albicans and Paecileomyces variotti.

Synthesis of biologically active 4-amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones and their Schiff bases

Three arylpyruvic acids 2 are condensed with thiocarbohydrazide (3) in aqueous ethanol to yield 4-amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 4. In a modified method these title compounds 4 have also been prepared by direct condensation of the