202664-83-3

Basic information

• Product Name: 4-(acetylamino)-2-hydroxy-3-(2-oxoethyl)benzoic acid methyl ester
• Synonyms: 4-(acetylamino)-2-hydroxy-3-(2-oxoethyl)benzoic acid methyl ester
• CAS NO: 202664-83-3
• Molecular Weight: 251.239
• Mol File: 202664-83-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(acetylamino)-2-hydroxy-3-(2-oxoethyl)benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(acetylamino)-2-hydroxy-3-(2-oxoethyl)benzoic acid methyl ester(202664-83-3)
• EPA Substance Registry System: 4-(acetylamino)-2-hydroxy-3-(2-oxoethyl)benzoic acid methyl ester(202664-83-3)

Safety Data

• Hazardous Substances Data: 202664-83-3(Hazardous Substances Data)

Upstream product

• 110751-41-2 methyl 2-hydroxy-3-allyl-4-acetaminobenzoate 
• 91958-13-3 methyl 2-allyloxy-4-acetylaminobenzoate 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 

Downstream Products

• 123654-26-2 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid 
• 149466-67-1 methyl 4-acetylamino-2,3-dihydrobenzo[b]furan-7-carboxylate 
• 143878-29-9 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid methyl ester 
• 202664-85-5 methyl 4-acetylamino-2-hydroxy-3-(2-hydroxyethyl)benzoate 

Relevant articles and documents

4 - (acetyl amino) - 2-hydroxy-3 - (2-oxo-ethyl) benzoic acid synthesis of methyl

The invention relates to a synthetic method of 4-(acetyl amino)-2-hydroxy-3-(2-carbonyl ethyl) methyl benzoate. The method comprises the following steps of: adding the 4-(acetyl amino)-2-hydroxy-3-(2-allyl) methyl benzoate into an ether solvent, then adding a water solution of osmium potassium, finally adding water solution of an oxidant periodate, reacting under the condition of room temperature, wherein the product is insoluble to the solvent; carrying out suction filtration to obtain the 4-(acetyl amino)-2-hydroxy-3-(2-aldehyde agent ethyl) methyl benzoate crude product; and pulping and purifying the 4-(acetyl amino)-2-hydroxy-3-(2-aldehyde agent ethyl) methyl benzoate crude product with water. In comparison with the conventional process, the process is greatly improved and has the following advantages: 1) nearly no organic or inorganic waste solvent is generated; 2) the crude product can be obtained through directly carrying out centrifuging after reaction; and 3) purification can be achieved by pulping only with a small amount of water to remove inorganic salt out of the crude product. Therefore, the process can be easily put into industrial production, and the production cost is greatly lowered by reuse of the catalyst.