20271-39-0

Usage

Chemical class

Triazoles

Contains groups

Phenyl, amino, nitrile

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Biological activities

Antimicrobial, anticancer

Potential use

Ligand in coordination chemistry, building block in organic synthesis

Versatility

Applications in pharmaceuticals, agrochemicals, and materials science

Upstream product

• 20317-25-3 5-amino-1-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 622-37-7 Phenyl azide 
• 109-77-3 malononitrile 
• 62-53-3 aniline 
• 17466-00-1 7-chloro-3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 

Downstream Products

• 163071-23-6 5-amino-1-phenyl-1H-1,2,3-triazole-4-carbothioamide 
• 61456-87-9 1-phenyl-1H-1,2,3-triazole-4-carbonitrile 
• 103912-93-2 4-Amino-1-phenyl-1H-bis[1,2,3]triazolo[1,5-a;4',5'-e]pirimidine-6-carboxylic acid ethyl ester 
• 103912-89-6 4-amino-1,6-diphenyl-1H-bis<1,2,3>triazolo<1,5-a:4',5'-e>pyrimidine 
• 103912-91-0 4-amino-6-cyano-1-phenyl-1H-bis<1,2,3>triazolo<1,5-a:4',5'-e>pyrimidine 
• 163071-37-2 5-azido-1-phenyl-4-(4-phenylthiazol-2-yl)-1,2,3-triazole 
• 163071-24-7 3-Phenyl-5-(4-phenyl-thiazol-2-yl)-3H-[1,2,3]triazol-4-ylamine 
• 103912-98-7 5-chloro-4-cyano-1-phenyl-1,2,3-triazole 
• 103912-80-7 5-azido-4-cyano-1-phenyl-1,2,3-triazole 

Relevant academic research and scientific papers

Selective Synthesis of Functionally Substituted 1,2,3-Triazoles

Abstract: Different conditions were used to achieve selective formation of4.5-disubstituted 1-aryl(hetaryl)-1,2,3-triazoles via cycloaddition of thecorresponding enolates and aryl or hetaryl azides. Optimal conditions were foundfor the bromination of 1-(5

Design and synthesis of a novel class of carbonic anhydrase-IX inhibitor 1-(3-(phenyl/4-fluorophenyl)-7-imino-3H-[1,2,3]triazolo[4,5d]pyrimidin 6(7H)yl)urea

Carbonic anhydrase IX (CAIX) is a promising target in cancer therapy especially in the case of hypoxia-induced tumors. The selective inhibition of CA isozymes is a challenging task in drug design and discovery process. Here, we performed fluorescence-bind

Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines

[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3- triazoles

Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a

THERMOLYSIS OF 4-HETEROARYL SUBSTITUTED 5-AZIDO-1H-1,2,3-TRIAZOLES : COMPETITION BETWEEN REARRANGEMENT AND DECOMPOSITION

5-Azidotriazoles bearing a thiazole or pyridine ring at the 4-position were synthesized and thermolyzed at 60 deg C.Whereas the 5-azido-4-(thiazol-2-yl)triazole 4 decomposed with extrusion of nitrogen and formation of the triazene 5 as the sole reaction p

Triazolo[4,5-d]pyrimidines. X. Halogen-metal exchange reaction of 7-halo-3-phenyl-3H-1,2,3-triazolo[4,5-d)pyrimidines with butyllithium

The amino group at the 7-position on the 3H-1,2,3-triazolo[4,5-d]pyrimidine ring was converted into halogen atoms by treatment with isopentyl nitrite in halomethanes, in satisfactory yields. The halogen-metal exchange reaction between 7-iodo-3-phenyl-3H-1

SYNTHESIS OF 5-DIAZOMETHYL SUBSTITUTED v-TRIAZOLOPYRIMIDINES

The condensation of 5-azido-4-cyano-1-substituted-1,2,3-triazoles with active methylene nitriles in the presence of a strong base yields the title compounds 6 which exist in equilibrium with the tricyclic systems 5.The equilibrium position is shifted towa