202753-56-8

Basic information

• Product Name: 4-BROMOTRYPTOPHOL
• Synonyms: 1H-INDOLE-3-ETHANOL, 4-BROMO-;4-BROMOTRYPTOPHOL;4-BROMOTRYPTOPHOL, 98+%;2-(4-bromo-1H-indol-3-yl)ethanol;4-Bromo-1H-indole-3-ethanol
• CAS NO: 202753-56-8
• Molecular Formula: C₁₀H₁₀BrNO
• Molecular Weight: 240.1
• Mol File: 202753-56-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 411.5 °C at 760 mmHg
• Flash Point: 202.6 °C
• Appearance: /
• Density: 1.618 g/cm³
• Vapor Pressure: 1.65E-07mmHg at 25°C
• Refractive Index: 1.699
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMOTRYPTOPHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOTRYPTOPHOL(202753-56-8)
• EPA Substance Registry System: 4-BROMOTRYPTOPHOL(202753-56-8)

Safety Data

• Hazardous Substances Data: 202753-56-8(Hazardous Substances Data)

Usage

Description

4-Bromotryptophol is a chemical compound belonging to the tryptophol family, derived from tryptophan with a bromine atom at the 4th position of the indole ring. 4-BROMOTRYPTOPHOL is known for its unique chemical and physical properties, which are attributed to the presence of the bromine atom. It is widely recognized for its valuable biological activities, such as antimicrobial, antifungal, and algicidal properties, and has demonstrated significant effects as a serotonin receptor antagonist, making it a promising candidate for treating various health conditions. However, it is important to note that details regarding its toxicity and safety are limited, and there are potential risks associated with improper handling.

Uses

Used in Scientific Research:
4-Bromotryptophol is used as a research compound for its antimicrobial, antifungal, and algicidal properties, making it valuable in the study of biological activities and potential applications in various fields.
Used in Pharmaceutical Development:
4-Bromotryptophol is used as a pharmaceutical agent for its role as a serotonin receptor antagonist, which can be beneficial in treating a variety of health conditions. Its potential applications in this industry are currently being explored, with a focus on understanding its safety and efficacy.
Used in Chemical Synthesis:
4-Bromotryptophol is used as a chemical intermediate in the synthesis of other compounds, particularly those with potential applications in the pharmaceutical and biotechnology industries. Its unique properties make it a useful building block for the development of new drugs and therapeutic agents.
Used in Environmental Applications:
4-Bromotryptophol is used as an algicide to control the growth of algae in aquatic environments, which can be harmful to ecosystems and water quality. Its effectiveness in this application is currently being studied, with a focus on understanding its impact on the environment and potential for use in various settings.

InChI:InChI=1/C10H10BrNO/c11-8-2-1-3-9-10(8)7(4-5-13)6-12-9/h1-3,6,12-13H,4-5H2

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 960148-53-2 2-(4-bromo-1H-indol-3-yl)-2-oxoacetyl chloride 
• 52488-36-5 4-bromo-1H-indole 
• 214915-73-8 ethyl (4-bromo-indol-3-yl)glyoxylate 
• 89245-41-0 4-bromo-3-indoleacetic acid 
• 425640-16-0 methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate 

Downstream Products

• 936252-66-3 4-bromo-3-(p-toluenesulfonyloxyethyl)-1-(p-toluenesulfonyl)indole 
• 898746-58-2 tert-butyl 4-bromo-3-(2-hydroxyethyl)-1H-indole-1-carboxylate 

Relevant articles and documents

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Expedient synthetic approaches to the highly functionalized polycyclic alkaloids communesin F and perophoramidine are described using a unified approach featuring a key decarboxylative allylic alkylation to access a crucial and highly congested 3,3-disubs

Asymmetric Synthesis of Lysergic Acid via an Intramolecular (3+2) Dipolar Cycloaddition/Ring-Expansion Sequence

An effective, potentially scalable asymmetric synthesis of lysergic acid, a core component of the ergot alkaloid family, is reported. The synthesis features the strategic combination of an intramolecular azomethine ylide cycloaddition and Cossy-Charette r

Scope of the Reactions of Indolyl- and Pyrrolyl-Tethered N-Sulfonyl-1,2,3-triazoles: Rhodium(II)-Catalyzed Synthesis of Indole- and Pyrrole-Fused Polycyclic Compounds

An efficient synthesis of tetrahydrocarboline-type products and polycyclic spiroindolines has been achieved. The transformation proceeds via rhodium(II)-catalyzed intramolecular annulations of indolyl- and pyrrolyl-tethered N-sulfonyl-1,2,3-triazoles. The reaction could be tuned toward either the formal [3 + 2] cycloaddition or the C-H functionalization reaction depending on the electronic and structural features of the substrates, leading to the production of a variety of structurally related heterocyclic compounds.