2028-12-8

Basic information

• Product Name: 6-carbamoylcyclohex-3-ene-1-carboxylic acid
• Synonyms: 3-Cyclohexene-1-carboxylic acid, 6-(aminocarbonyl)-
• CAS NO: 2028-12-8
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.1778
• Mol File: 2028-12-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 438.2°C at 760 mmHg
• Flash Point: 218.8°C
• Density: 1.297g/cm³
• Vapor Pressure: 6.67E-09mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 6-carbamoylcyclohex-3-ene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-carbamoylcyclohex-3-ene-1-carboxylic acid(2028-12-8)
• EPA Substance Registry System: 6-carbamoylcyclohex-3-ene-1-carboxylic acid(2028-12-8)

Safety Data

• Hazardous Substances Data: 2028-12-8(Hazardous Substances Data)

Upstream product

• 85-43-8 trans-4-Cylohexene-1,2-dicarboxylic anhydride 
• 85-43-8 1,2,3,6-Tetrahydrophthalic anhydride 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 28907-18-8 (1S,2R)-Cyclohex-4-ene-1,2-dicarboxylic acid diamide 
• 1469-48-3 cis-1,2,3,6-Tetrahydrophthalimide 
• 28907-19-9 (1R,2S)-Cyclohex-4-ene-1,2-dicarbonitrile 

Downstream Products

• 85-40-5 1,2,3,6-tertahydrophthalimide 
• 98769-63-2 ((1S,6S)-6-Hydroxymethyl-cyclohex-3-enyl)-carbamic acid ethyl ester 
• 98769-61-0 trans-2-(p-clorophenyl)-1,2,4a,5,8,8a-hexahydro-4H-3,1-benzoxazine 
• 98769-56-3 trans-2-(hydroxymethyl)-4-cyclohexenyl-1-amine 
• 2305-26-2 cis-1,2,3,6-tetrahydrophthalic acid 
• 54162-90-2 trans-2-amino-4-cyclohexene-1-carboxylic acid 
• 54162-90-2 (cis)-6-aminocyclohex-3-ene-1-carboxylic acid 
• 6294-84-4 cis-1-carboxy-2-(aminocarboxyl)-2-cyclohexane 
• 98769-63-2 ((1S,6R)-6-Hydroxymethyl-cyclohex-3-enyl)-carbamic acid ethyl ester 
• 24717-02-0 cis-2-aminocyclohexanecarbohydrazide 
• 24716-87-8 cis-decahydroquinazoline 
• 24716-89-0 cis-2-amino-1-aminomethylcyclohexane 
• 98769-61-0 cis-2-(p-clorophenyl)-1,2,4a,5,8,8a-hexahydro-4H-3,1-benzoxazine 
• 98769-56-3 cis-2-(hydroxymethyl)-4-cyclohexenyl-1-amine 

Relevant articles and documents

Intramolecular Influence of a Carboxylic Function on Platinium Blue Synthesis. A systematic Study of Complexes Originating from Acid Amides

The use of acid amide as ligand for obtaining platinium blue has been investigated.While blue compounds are generally obtained by using the hydrolysis product of cis-dichlorodiammineplatinum(II) as platinum surce, with such ligands the reaction occurs very readily using potassium tetrachloroplatinate(II).The role of the carboxylic function which offers here a primary ligating site to platinum is evidenced.The compounds obtained have been characterized by UV-visible spectral measurments, Ce(IV) oxydative titration , ESR spectroscopy, and magnetic properties.Antitumoral activity toward leukemia L1210 and sarcoma 180 is reported for two of thesecompounds.As a first step for this antitumor study, these compounds have been found to be inactive toward Leukemia while they presnt intersting activity toward Sarcoma.

Preparation method of 1,2,3,6-tetrahydrophthalimide

The invention provides a preparation method of 1,2,3,6-tetrahydrophthalimide. The preparation method comprises the following steps: a) mixing 1,2,3,6-tetrahydrophthalic anhydride with an ammonia source, and carrying out a low-temperature reaction to obtain a reaction intermediate, wherein the temperature of the low-temperature reaction is 0-30 DEG C; and b) carrying out a dehydration ring-closurereaction on the reaction intermediate obtained in the step a) in the presence of a solvent, carrying out cooling and recrystallizing to obtain the 1,2,3,6-tetrahydrophthalimide. According to the preparation method provided by the invention, a step-by-step method is adopted, a ring-opening reaction and a ring-closure reaction are separated to reduce side reactions, and a conventional heating process is not carried out in the whole process, so the generation of viscous colloidal byproducts in a temperature range of 80-110 DEG C can be effectively avoided, and high selectivity is realized, thereby improving product purity; meanwhile, reaction operation in a solvent is simple, conditions are easy to control, and environment friendliness is achieved; the overall two-step yield can reach 95% orhigher; moreover, no waste gas is generated in the reaction process, and redundant ammonia gas can be recycled, so environmental production cost is greatly saved.

Rhodococcus rhodochrous IFO 15564-mediated hydrolysis of alicyclic nitriles and amides: Stereoselectivity and use for kinetic resolution and asymmetrization

The stereocourse and the selectivity of the hydrolysis of alicyclic mono- and dinitriles and amides mediated by Rhodococcus rhodochrous IFO · 15564 has been examined. The stereochemistry of the substrates, as well as the nature of substituents and presence of double bonds in alicyclic rings greatly affected the rate of hydrolysis by nitrile hydratase and amidase. The rate difference between enantiomers or enantiotopic groups, in some cases, enabled kinetic resolution or asymmetrization. The highest enantioselectivity of amidase was observed in the hydrolysis of 5-benzoyloxy-3-cyclohexene-1- carboxamide (E>200), and both enantiomers of methyl 5-hydroxy-3-cyclohexene- 1-carboxylate thus became readily available.