202811-02-7

Upstream product

• 106891-32-1 N-methyl-N-(2-(thien-2-yl)ethyl)amine 
• 202810-95-5 N-methyl-N-((1R)-1-(N-methyl-N-(2-(thien-2-yl)ethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester 
• 147577-61-5 (2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid 
• 165949-84-8 3-<1'-<(tert-butyloxycarbonyl)amino>ethyl>benzoic acid 
• 202810-96-6 (2R)-N-methyl-2-(methylamino)-3-(2-naphthyl)-N-(2-(thien-2-yl)ethyl)propionamide 

Relevant academic research and scientific papers

New highly potent dipeptidic growth hormone secretagogues with low molecular weight

Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group. The compounds were highly potent in combination with high efficacy in a rat pituitary cell assay, being characterized with EC50 values down to 0.8 nM. Selected compounds were tested in in vivo animal models. The oral bioavailability in dogs was 16-44%. Also, the ED50 values of the compounds were determined both in dog and swine. (C) 2000 Editions scientifiques et medicales Elsevier SAS.