202822-74-0 Usage
Molecular structure
The compound has a complex molecular structure with multiple functional groups and heteroatoms.
Oxadiazole ring
The compound contains an oxadiazole ring, which is a five-membered ring with two nitrogen atoms and one oxygen atom.
Chloro-methoxyphenyl group
The compound features a chloro-methoxyphenyl group, which is a phenyl ring with a chlorine atom and a methoxy group attached.
Imidazole group
The compound also contains an imidazole group, which is a five-membered ring with two nitrogen atoms.
Trifluoromethyl group
The compound has a trifluoromethyl group, which is a carbon atom bonded to three fluorine atoms.
Phenyl ring with a nitrogen atom
The compound includes a phenyl ring with a nitrogen atom, which may contribute to its potential biological activity.
Potential applications
The compound may have potential applications in pharmaceuticals or agrochemicals due to its structural features.
Further research needed
Further research is required to fully understand the properties and potential uses of this chemical compound.
Molecular weight
The molecular weight of the compound is approximately 433.80 g/mol.
Appearance
The appearance of the compound is not provided in the material, but it is likely a solid due to its complex molecular structure.
Solubility
The solubility of the compound is not provided in the material, but it may be soluble in organic solvents such as dimethyl sulfoxide (DMSO) or methanol.
Stability
The stability of the compound is not provided in the material, but it may be sensitive to light, heat, or moisture due to the presence of various functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 202822-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,8,2 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 202822-74:
(8*2)+(7*0)+(6*2)+(5*8)+(4*2)+(3*2)+(2*7)+(1*4)=100
100 % 10 = 0
So 202822-74-0 is a valid CAS Registry Number.
202822-74-0Relevant academic research and scientific papers
3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3, 4-oxadiazol-2(3H)-one, BMS-191011: Opener of large-conductance Ca 2+-activated potassium (maxi-K) channels, identification, solubility, and SAR
Romine, Jeffrey L.,Martin, Scott W.,Meanwell, Nicholas A.,Gribkoff, Valentin K.,Boissard, Christopher G.,Dworetzky, Steven I.,Natale, Joanne,Moon, Sandra,Ortiz, Astrid,Yeleswaram, Swamy,Pajor, Lorraine,Gao, Qi,Starrett Jr., John E.
, p. 528 - 542 (2007/10/03)
Compound 8a (BMS-191011), an opener of the cloned large-conductance, Ca2+-activated potassium (maxi-K) channel, demonstrated efficacy in in vivo stroke models, which led to its nomination as a candidate for clinical evaluation. Its maxi-K channel opening properties were consistent with its structural topology, being derived by combining elements from other known maxi-K openers. However, 8a suffered from poor aqueous solubility, which complicated elucidation of SAR during in vitro evaluation. The activity of 8a in in vivo stroke models and studies directed toward improving its solubility are reported herein. Enhanced solubility was achieved by appending heterocycles to the 8a scaffold, and a notable observation was made that inclusion of a simple amino group (anilines 8k and 8l) yielded excellent in vitro maxi-K ion channel opening activity and enhanced brain-to-plasma partitioning compared to the appended heterocycles.
