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202827-81-4

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202827-81-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 202827-81-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,8,2 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 202827-81:
(8*2)+(7*0)+(6*2)+(5*8)+(4*2)+(3*7)+(2*8)+(1*1)=114
114 % 10 = 4
So 202827-81-4 is a valid CAS Registry Number.

202827-81-4Relevant articles and documents

Discovery and Pharmacophore Studies of Novel Pyrazole-Based Anti-Melanoma Agents

Li, Qing-Shan,Lü, Xian-Hai,Yang, Yang,Ruan, Ban-Feng,Yao, Ri-Sheng,Liao, Chen-Zhong

, p. 116 - 132 (2015/10/19)

Due to the rising incidence and lack of effective treatments, malignant melanoma is the most dangerous form of skin cancer, so that new treatment strategies are urgently needed. Several recent developments indicate that the V600E mutant BRAF (BRAFV60

Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors

Li, Cui-Yun,Li, Qing-Shan,Yan, Li,Sun, Xiao-Guang,Wei, Ran,Gong, Hai-Bin,Zhu, Hai-Liang

, p. 3746 - 3755 (2012/08/28)

A series of novel 4,5-dihydropyrazole derivatives containing niacinamide moiety as potential V600E mutant BRAF kinase (BRAFV600E) inhibitors were designed and synthesized. Results of the bioassays against BRAF V600E and WM266.4 human

Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents

Li, Qing-Shan,Zhang, Yan-Bin,Dong, Jing-Jun,Zhou, Wen-Ping,Yang, Yang,Zhu, Hai-Liang,Lv, Xian-Hai

, p. 6596 - 6601,6 (2012/12/12)

There is an accumulating body of experimental evidences validating oncogenic BRAFV600E as a therapeutic target and offering opportunities for anti-melanoma drug development. Encouraged by the positive results of pyrazole derivatives as BRAFsup

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