92873-00-2

Upstream product

• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 5467-74-3 4-Bromophenylboronic acid 
• 99-90-1 para-bromoacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1260620-91-4 4-(4-bromophenyl)-6-(4-methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 1333466-23-1 5-(4-bromophenyl)-3-(4-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1415722-20-1 3-(benzylamino)-3-(4-bromophenyl)-1-(4-methoxyphenyl)propan-1-one 
• 1586019-07-9 (S)-3-(4-bromophenyl)-3-(diphenylphosphinyl)-1-(4-methoxyphenyl)propan-1-one 
• 1450853-34-5 C₂₅H₁₇BrO₄ 
• 688743-30-8 4-(p-bromophenyl)-6-(p-methoxyphenyl)-2-phenylpyrimidine 
• 1333466-20-8 5-dihydro-3,5-diphenylpyrazole-1-carbothioamide 
• 69704-15-0 α-4-hydroxy phenyl β-4'methoxy benzoyl ethylene 

Relevant academic research and scientific papers

Crystal engineering with pyrazolyl-thiazole derivatives: Structure-directing role of π-stacking and σ-hole interactions

The synthesis and X-ray characterization of 1-(2-(3-(4-bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-methylthiazol-5-yl)ethanone (7), ethyl 2-(5-(4-bromophenyl)-3-(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)thiazole-4-carboxylate (8) and 2-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-N′-(2-hydroxy-3-methoxybenzylidene)thiazole-4-carbohydrazide (10) are described in this manuscript. The structure-directing role of a variety of noncovalent interactions has been analyzed energetically using DFT calculations and Hirshfeld surface analysis. Moreover, the existence and importance of halogen and chalcogen bonding interactions have been analyzed by using the quantum theory of atoms in molecules and the noncovalent interaction index (NCIplot).

Catalyst- and acid-free Markovnikov hydration of alkynes in a sustainable H2O/ethyl lactate system

An efficient and sustainable protocol for the hydration of alkynes has been developed under metal/acid/catalyst/ligand-free conditions in a water/ethyl lactate mixture. The hydrogen-bond network in the ethyl lactate and water mixture plays a crucial and decisive role in activating the alkynes for hydration to afford the corresponding methyl ketones. This strategy gives the Markovnikov (ketone) addition product selectively over other possible products. The essential role of hydrogen bonding has been confirmed by experimental and theoretical techniques. A probable mechanism has been suggested by various control tests. The efficacy of the method has been further explored for the competent production of value-added α,β-unsaturated carbonyl compounds through the reaction of aldehydes with alkynes as ketonic surrogates. The environmentally benign hydration method takes place under mild conditions, has broad functional-group compatibility, and uses the ethyl lactate/water (1:3) medium as a “green alternative” in the absence of any hazardous, harmful, or expensive substances.

Oxygen as single oxidant for two steps: Base-free one-pot Pd(ii)-catalyzed alcohol oxidation & arylation to halogen-intact β-aryl α,β-enones

Using oxygen as the sole oxidant for two steps, we developed a new method to synthesize β-aryl α,β-enones by fine-tuning the Pd(ii)-catalyzed oxidation of allyl alcohol to subsequent arylation with arylboronic acids, arylboronic ester and aryltrifluoroborate salt. This one-pot green method does not require copper salt, base, and intermediate isolation. Halogen-bearing chalcones, dibenzylideneacetones and arylalkyl enones were synthesized in good yields. This journal is