202850-01-9Relevant articles and documents
Synthesis of fluorescent C24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin
Novotny, Jakub,Pospěchová, Kate?ina,Hrabálek, Alexandr,?áp, Robert,Vávrová, Kate?ina
, p. 6975 - 6977 (2009)
Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools.