202864-55-9Relevant academic research and scientific papers
Nickel-catalyzed coupling reaction of sterically congested cis bromides and lithium alkenylborates
Kobayashi, Yuichi,Nakayama, Yuji,Mizojiri, Ryo
, p. 1053 - 1062 (1998)
Lithium alkenyl berates of general structure 5 (R(T) = alkenyl) couple with cis bromides 1 at room temperature overnight in the presence of NiCl2(PPh3)2 as a catalyst to furnish dienes of general structure 3 with retention of the olefin geometries present in both coupling partners. By using this reaction, cis,trans dienes 3 (R = TBDMS, TES, TBDPS; R1 = n-C5H11, c-C6H11; R2 = H; R3 = n-C5H11, Ph) and cis,cis diene 3 (R = TBDMS; R1 = R2 = n-C5H11; R3 = H) are synthesized in good yields.
