202865-78-9

Basic information

• Product Name: 2-BROMO-5-FLUORO-4-METHYLANILINE
• Synonyms: 2-BROMO-5-FLUORO-4-METHYLANILINE;2-Bromo-5-fluoro-4-methylaniline 98%;2-Bromo-5-fluoro-4-methylaniline98%;BENZENAMINE,2-BROMO-5-FLUORO-4-METHYL;2-broMo-5-fluoro-4-MethylbenzenaMine;4-Amino-5-bromo-2-fluorotoluene, 2-Bromo-5-fluoro-p-toluidine;2-Bromo-5-fluoro-4-methyl-phenylamine
• CAS NO: 202865-78-9
• Molecular Formula: C₇H₇BrFN
• Molecular Weight: 204.04
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds
• Mol File: 202865-78-9.mol

Chemical Properties

• Melting Point: 39-41°C
• Boiling Point: 245.262 °C at 760 mmHg
• Flash Point: 102.131 °C
• Appearance: /
• Density: 1.589 g/cm³
• Vapor Pressure: 0.029mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.95±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-5-FLUORO-4-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-FLUORO-4-METHYLANILINE(202865-78-9)
• EPA Substance Registry System: 2-BROMO-5-FLUORO-4-METHYLANILINE(202865-78-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 202865-78-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-5-FLUORO-4-METHYLANILINE is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-5-FLUORO-4-METHYLANILINE serves as a key intermediate in the synthesis of compounds with pesticidal or herbicidal activity. Its incorporation into these products can enhance their effectiveness in protecting crops and managing pests.
Used in Dye Industry:
2-BROMO-5-FLUORO-4-METHYLANILINE is utilized as an intermediate in the production of dyes, where its structural features contribute to the color and properties of the final dye products, offering a range of applications in textiles, plastics, and other industries.
Used in Specialty Chemicals Production:
2-BROMO-5-FLUORO-4-METHYLANILINE is also employed in the manufacture of specialty chemicals, where its unique attributes can be leveraged to create high-value products with specific applications in various industrial sectors.
Used as a Reagent in Organic Synthesis:
2-BROMO-5-FLUORO-4-METHYLANILINE functions as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the formation of complex organic molecules for a wide range of applications.

InChI:InChI=1/C7H7BrFN/c1-4-2-5(8)7(10)3-6(4)9/h2-3H,10H2,1H3

Upstream product

• 452-77-7 3-fluoro-4-methyl-phenylamine 

Downstream Products

• 201849-18-5 1-bromo-2-chloro-4-fluoro-5-methylbenzene 
• 1037206-84-0 2-amino-4-fluoro-5-methylbenzonitrile 
• 1296770-64-3 3-(2-azido-4-fluoro-5-methylphenyl)pyridine 
• 1296770-79-0 1-methyl-3-(2-azido-4-fluoro-5-methylphenyl)pyridinium triflate 
• 1296770-59-6 3-(2-amino-4-fluoro-5-methylphenyl)pyridine 
• 1393607-00-5 4-(2-amino-4-fluoro-5-methylphenyl)pyridine 
• 1037206-88-4 7-fluoro-6-methylquinazolin-4(3H)-one 
• 1037206-86-2 methyl 2-amino-4-fluoro-5-methylbenzoate 

Relevant articles and documents

Direct Tryptophols Synthesis from 2-Vinylanilines and Alkynes via C - C Triple Bond Cleavage and Dioxygen Activation

An unexpected metal-free C - C triple bond cleavage, dioxygen activation, and reassembly into tryptophol derivatives has been developed. This chemistry provides a novel, simple, and efficient approach to highly valuable tryptophol derivatives from simple substrates under mild conditions. The mechanistic studies may promote the discovery of new methodologies through C-C bond cleavage and dioxygen activation.

Discovery of SCH 900188: A potent hepatitis C virus NS5B polymerase inhibitor prodrug as a development candidate

Starting from indole-based hepatitis C virus (HCV) NS5B polymerase inhibitor lead compound 1, structure modifications were performed at multiple indole substituents to improve potency and pharmacokinetic (PK) properties. Bicyclic quinazolinone was found to be the best substituent at indole nitrogen, while 4,5-furanylindole was identified as the best core. Compound 11 demonstrated excellent potency. Its C2 N,N-dimethylaminoethyl ester prodrug 12 (SCH 900188) demonstrated significant improvement in PK and was selected as the development candidate.

5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF

The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS

The present invention relates to 2,3-Substituted Azaindole Derivatives, compositions comprising at least one 2,3-Substituted Azaindole Derivatives, and methods of using the 2,3-Substituted Azaindole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient

4, 5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS

The present invention relates to 4, 5 - ring annulated indole derivatives of formula ( I ), compositions comprising at leas t one 4, 5 - ring annulated indole derivatives, and methods of using the 4, 5 - ring annulated ^ndole derivatives for treating or preventing a viral inf ection or a virus - related disorder in a patient, (I) wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6- membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R1, R2, R3, R6. R7 and R10 are as described herein.

4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS

The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.