202867-17-2Relevant academic research and scientific papers
Synthesis, characterization and preliminary anticonvulsant evaluation of new indoline-2,3-dione derivatives
Karali,Capan,Ergenc,Guersoy
, p. 277 - 287 (2007/10/03)
New esters (2b and 2c) and hyrazides (3b and 3c) were synthesized from 4-(4-bromo/chlorophenyl)-5-(2-furanyl)-2,4-dihydro-3H,1,2,4-triazole-3- thiones (1b and 1c). Subsequent treatment of 3a-c and 2-furoic acid hydrazide (5) with indoline-2,3-dione (4a) and 5-bromoindoline-2,3-dione (4b) furnished the corresponding 3-hydrazono-1H-2-indolinones (6a-f, 7a and 7b) which exist as isomeric mixtures in solution. Reaction of 6a, 7a and 7b with acetic anhydride yielded the acetylated acyclic derivatives (9, 11a/12a and 11b/12b). N-acetylindoline-2,3-dione (13) was condensed with 5 to give 14. The structures of all the compounds were determined by analytical and spectral (IR, 1H-NMR, 13C-NMR, CIMS,(CH4), EIMS) methods. 6a, 6b, 7a and 7b were evaluated for anticonvulsant activity.
