202867-18-3Relevant academic research and scientific papers
Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4-thiazolidinone and 1,2,4-triazole-3-thione derivatives
Dincel, Efe Do?ukan,Ulusoy-Güzeldemirci, Nuray,?atana, Dilek,Kü?ükbasmac?, ?mer
, p. 195 - 205 (2021)
A series of novel hydrazinecarbothioamide (5a,c,f), 4-thiazolidinone (6a-e), and 1,2,4-triazole-3-thione (7a-d) were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H-NMR, 13C-NMR, mass and elemental analysis. All novel derivatives were evaluated for their antibacterial and antifungal activities against nine diverse microorganisms. According to the biological activity studies of the compounds, 6d, 7c and 7d displayed hope promising antibacterial activity. Furthermore, 6d displayed potent antifungal activity. Consequently, the obtained results revealed that 6d, 7c and 7d present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.
Synthesis, characterization and preliminary anticonvulsant evaluation of new indoline-2,3-dione derivatives
Karali,Capan,Ergenc,Guersoy
, p. 277 - 287 (2007/10/03)
New esters (2b and 2c) and hyrazides (3b and 3c) were synthesized from 4-(4-bromo/chlorophenyl)-5-(2-furanyl)-2,4-dihydro-3H,1,2,4-triazole-3- thiones (1b and 1c). Subsequent treatment of 3a-c and 2-furoic acid hydrazide (5) with indoline-2,3-dione (4a) and 5-bromoindoline-2,3-dione (4b) furnished the corresponding 3-hydrazono-1H-2-indolinones (6a-f, 7a and 7b) which exist as isomeric mixtures in solution. Reaction of 6a, 7a and 7b with acetic anhydride yielded the acetylated acyclic derivatives (9, 11a/12a and 11b/12b). N-acetylindoline-2,3-dione (13) was condensed with 5 to give 14. The structures of all the compounds were determined by analytical and spectral (IR, 1H-NMR, 13C-NMR, CIMS,(CH4), EIMS) methods. 6a, 6b, 7a and 7b were evaluated for anticonvulsant activity.
