202867-72-9

Upstream product

• 191539-69-2 (1R,2S,3S,4S,7S)-2,3-Bis-(diphenyl-phosphinoyl)-bicyclo[2.2.1]heptan-7-ol 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 
• 202867-70-7 2-[(1R,2S,3S,4S,7S)-2,3-Bis-(diphenyl-phosphinoyl)-bicyclo[2.2.1]hept-7-yloxy]-N,N-diethyl-acetamide 

Relevant academic research and scientific papers

Synthesis of a novel type of chiral bisphosphine ligand (NORPHOS-7-NEt2) with an amino group for neighboring participation in asymmetric allylic alkylation

A new chiral bisphosphine ligand, NORPHOS-T-NEt2, with an amino group has been prepared. It has been applied to the Pd-catalyzed asymmetric allylic alkylation of rac-(E)-diphenyl-2-propenyl pivalate upon using (25,3S,7R)-NORPHOS-7-NEt2 (1) (M-Chirality) having an amino group on the ligand, the same absolute configuration product was obtained as compared to using (2R,3R)-NORPHOS (P-Chirality). This result clearly indicated the possibility of the interaction of the amino group on the ligand with the incoming nucleophile.