202867-95-6

Upstream product

• 100-51-6 benzyl alcohol 

Downstream Products

• 837359-97-4 (1R,2S)-2-amino-cyclohexanecarboxylic acid methyl ester 
• 202868-04-0 (1R,2S)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-3-phenyl-propionylamino]-cyclohexanecarboxylic acid 
• 202868-09-5 C₃₉H₄₈N₆O₇ 
• 202868-07-3 ((R)-1-{(1S,2R)-2-[(S)-1-(Benzyloxycarbonylamino-imino-methyl)-2-oxo-piperidin-3-ylcarbamoyl]-cyclohexylcarbamoyl}-2-phenyl-ethyl)-methyl-carbamic acid benzyl ester 
• 189101-43-7 (1R,2S)-(-)-2-aminocyclohexane-1-carboxylic acid 
• 202867-96-7 2-benzyloxycarbonylamino-cyclohexanecarboxylic acid 

Relevant academic research and scientific papers

5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Efficient asymmetric synthesis of unnatural β-amino acids

The simple and highly enantioselective methanolysis of cyclic meso-anhydrides mediated by cinchona alkaloids leads to a broad variety of dicarboxylic acid mono-methyl esters with up to 99% ee. From these products, unnatural N-protected β-amino esters can be obtained by means of Curtius degradation of the corresponding acyl azides. Subsequent cleavage of the protecting groups leads to the free β-amino acids in excellent yields. By enantiomer differentiating opening of racemic anhydrides, synthetically highly useful regioisomeric amino acid esters become readily available.