202871-97-4Relevant academic research and scientific papers
Cyclization of 5-alkynones with chromium alkylidene equivalents generated: In situ from gem -dichromiomethanes
Murai, Masahito,Taniguchi, Ryuji,Kurogi, Takashi,Shunsuke, Moritani,Takai, Kazuhiko
, p. 9711 - 9714 (2020)
A rare example of cyclization with 5-alkynones, which possess non-polar alkynyl and less electrophilic polar keto carbonyl groups, was demonstrated. The key to promoting carbene/alkyne metathesis followed by alkylidenation with pendant CO double bonds was the Schrock-type nucleophilic reactivity of the generated chromium carbene equivalents from readily available diiodomethanes and CrCl2 by simple heating.
