202932-04-5

Basic information

• Product Name: 5-Methyl-2-thiazolemethanol
• Synonyms: 5-Methyl-2-thiazolemethanol;(5-methyl-2-thiazolyl)methanol
• CAS NO: 202932-04-5
• Molecular Formula: C₅H₇NOS
• Molecular Weight: 129.182
• Mol File: 202932-04-5.mol

Chemical Properties

• Boiling Point: 225.026 °C at 760 mmHg
• Flash Point: 89.893 °C
• Appearance: /
• Density: 1.263
• Vapor Pressure: 0.05mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• PKA: 13.14±0.10(Predicted)
• CAS DataBase Reference: 5-Methyl-2-thiazolemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-2-thiazolemethanol(202932-04-5)
• EPA Substance Registry System: 5-Methyl-2-thiazolemethanol(202932-04-5)

Safety Data

• Hazardous Substances Data: 202932-04-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Methyl-2-thiazolemethanol is used as a reagent for the preparation of functionalized tetrahydro(ethano)triazolo[3,4-a]phthalazines. These compounds serve as selective GABAA receptor agonists, which play a crucial role in the central nervous system by modulating neuronal excitability. The GABAA receptor agonists have potential applications in the treatment of various neurological and psychiatric disorders, such as anxiety, epilepsy, and insomnia.
In addition to its use in the pharmaceutical industry, 5-Methyl-2-thiazolemethanol may also find applications in other industries, such as:
Used in Chemical Synthesis:
5-Methyl-2-thiazolemethanol can be employed as a building block or intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its unique chemical structure allows for further functionalization and modification, enabling the development of novel molecules with diverse applications.
Used in Flavor and Fragrance Industry:
Due to its strong and characteristic odor, 5-Methyl-2-thiazolemethanol may be utilized in the flavor and fragrance industry as a component in the creation of various scent profiles. It can contribute to the development of new and innovative fragrances, as well as enhance the aroma of existing products.
Used in Research and Development:
5-Methyl-2-thiazolemethanol can be a valuable tool in research and development, particularly in the fields of organic chemistry, medicinal chemistry, and materials science. It can be used to study the properties and reactivity of thiazole-containing compounds, as well as to develop new synthetic methods and strategies for the preparation of complex molecules.

InChI:InChI=1/C5H7NOS/c1-4-2-6-5(3-7)8-4/h2,7H,3H2,1H3

Upstream product

• 13838-78-3 5-methyl-1,3-thiazole-2-carbaldehyde 

Downstream Products

• 921145-23-5 2-(chloromethyl)-5-methylthiazole 

Relevant articles and documents

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS

The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particulalrly FabI inhibitors. Formula(I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.

Pyrazolo-triazine derivatives as ligands for GABA receptors

Compounds according to Formula (I): or a salt or prodrug thereof, have good affinity as ligands for the alpha2 and/or alpha3 subunit of the human GABAAreceptor and are useful for treatment of disorders of the central nervous system, including a