202932-19-2

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 141022-85-7 (4S,5R)-4-methyl-5-phenyl-3-phenylacetyloxazolidin-2-one 

Downstream Products

• 1040-59-1 (R)-3-Benzyloxycarbonylamino-2-phenyl-propionic acid 
• 1008-63-5 (R)-α-phenyl-β-alanine 
• 161583-20-6 [(R)-3-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester 
• 202932-25-0 (S)-4-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-3-phenyl-butyric acid 

Relevant academic research and scientific papers

Enantioselective synthesis of 2-substituted 3-aminopropanoic acid (β-alanine) derivatives which are β-analogues of aromatic amino acids

3-Aminopropanoic acid derivatives with a phenyl, 4-hydroxyphenyl, benzyl or indol-3-yl substituent at C-2 can be prepared enantioselectively by routes involving electrophilic attack of synthetic equivalents of [H2NCH2]+ upon enolates derived from chiral 3-acyl-1,3-oxazolidin-2-ones. tert-Butyl bromoacetate may be used as the electrophile, with subsequent introduction of nitrogen through the Curtius reaction, using the sequence of reagents (i) CF3CO2H; (ii) (PhO)2P(O)N3, Et3N, PhCH2OH; alternatively, direct electrophilic reaction with 1-[N-(benzyloxycarbonyl)aminomethyl]benzotriazole 4c or benzyl N-(acetoxymechyl)carbamate 2d introduces a protected aminomethyl group in a single step.