202932-48-7Relevant academic research and scientific papers
Transition metal complexes in organic synthesis, part 49. Development of novel chiral catalysts for the asymmetric catalytic complexation of prochiral cyclohexa-1,3-dienes by the tricarbonyliron fragment - Mechanism of the asymmetric catalysis and involvement of a dinuclear iron cluster
Kn?lker, Hans-Joachim,Goesmann, Helmut,Hermann, Holger,Herzberg, Daniela,Rohde, Guy
, p. 421 - 425 (1999)
Planar-chiral tricarbonyliron-diene complexes are obtained quantitatively in up to 73% ee by asymmetric catalytic complexation of prochiral cyclohexa-1,3-dienes. A series of novel chiral 1-azabuta-1,3-diene catalysts is investigated. The mechanism is shown to involve at least in some cases dinuclear iron cluster compounds which lead to a lower asymmetric induction.
High diastereoselective vinylogous Mannich reaction induced by O-pivaloylated d-galactosylamine as the chiral auxiliary: Stereoselective synthesis of 8-arylazocan-2-one
Cui, Bing,Hou, Gang,Cai, Yan,Miao, Zhiwei
, p. 1 - 7 (2013/06/27)
The diastereospecific formation of β-N-glycosidically linked α,β-unsaturated δ-amino aldehyde derivatives has been achieved with high yield via a vinylogous Mannich reaction. The reaction was performed by using a O-pivaloylated galactosyl amine as a chiral template and AlCl 3 as a promoter in THF. (S)-8-(p-Nitrophenyl) azocan-2-one can be stereoselective synthesized from (S) ethyl 7-galactosylamino-7-(p-nitrophenyl) hepta-2,4-dienoate by sequential hydrogenation of the double bond, cyclic lactam formation, and removal of the N-glycosidic auxiliary under basic conditions.
