203003-71-8Relevant academic research and scientific papers
Titanocene-based method for indole synthesis
Aoki, Kazumasa,Peat, Andrew J.,Buchwald, Stephen L.
, p. 3068 - 3073 (2007/10/03)
A new approach for the construction of indoles employing the air- and moisture-stable reagent Cp2TiCl2 is described. The key steps involved are (1) the intermolecular insertion reactions of an olefin and a titanocene- stabilized benzyne complex and (2) the Pd-catalyzed aryl amination reaction. The simplicity and availability of the requisite starting materials give the method a broad scope for the preparation of polysubstituted indoles.
