20306-74-5

Basic information

• Product Name: 2-(PROP-2-YN-1-YLOXY)PYRIMIDINE
• Synonyms: 2-(PROP-2-YN-1-YLOXY)PYRIMIDINE;1-(PROP-2-YN-1-YL)-1H-PYRAZOLE(WXC08364);1-(PROP-2-YN-1-YL)-1H-PYRAZOLE
• CAS NO: 20306-74-5
• Molecular Formula: C₆H₆N₂
• Molecular Weight: 106.13
• Mol File: 20306-74-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 172.6±23.0 °C(Predicted)
• Appearance: /
• Density: 0.92±0.1 g/cm3(Predicted)
• PKA: 1.67±0.10(Predicted)
• CAS DataBase Reference: 2-(PROP-2-YN-1-YLOXY)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PROP-2-YN-1-YLOXY)PYRIMIDINE(20306-74-5)
• EPA Substance Registry System: 2-(PROP-2-YN-1-YLOXY)PYRIMIDINE(20306-74-5)

Safety Data

• Hazardous Substances Data: 20306-74-5(Hazardous Substances Data)

Usage

General Description

2-(prop-2-yn-1-yloxy)pyrimidine is a chemical compound with the molecular formula C7H6N2O. It is an organic compound with a pyrimidine ring structure and a prop-2-yn-1-yloxy group attached to it. 2-(PROP-2-YN-1-YLOXY)PYRIMIDINE is commonly used in organic synthesis as a building block for creating various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and reactivity make it a versatile intermediate for producing a wide range of functionalized pyrimidine derivatives. The compound's properties and potential applications make it a valuable tool for chemical research and development in the pharmaceutical and agrochemical industries.

Upstream product

• 288-13-1 NH-pyrazole 
• 106-96-7 propargyl bromide 
• 6165-76-0 propargyl p-toluenesulfonate 

Downstream Products

• 1063631-68-4 trans-Pt(PPh₃)2(2-propargylpyrazole(-H))2 
• 1063631-70-8 cis-Pt(dppe)(2-propargylpyrazole(-H))2 
• 1357583-34-6 4-((1H-pyrazol-1-yl)methyl)-1-benzyl-1H-1,2,3-triazole 
• 1357583-37-9 4-((1H-pyrazol-1-yl)methyl)-1-phenyl-1H-1,2,3-triazole 
• 1087352-83-7 5-aminomethyl-3-[3-fluoro-4-(4-pyrazol-1-ylmethyl-[1,2,3]triazol-1-yl)-phenyl]-oxazolidin-2-one 
• 1629048-20-9 C₃₂H₃₃N₅O₅ 
• 1629048-23-2 C₄₁H₅₀N₇O₆P 
• 1629048-13-0 C₂₇H₂₇N₅O₅ 
• 1609103-25-4 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene 
• 1609103-15-2 1,2-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene 
• 1609103-27-6 1,3,5-tris((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene 
• 1403668-34-7 4-((1H-pyrazol-1-yl)methyl)-1-(4-nitrophenyl)-1H-1,2,3-triazole 
• 1403668-33-6 4-((1H-pyrazol-1-yl)methyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazole 
• 1087352-81-5 {3-[3-fluoro-4-(4-pyrazol-1-ylmethyl-[1,2,3]triazol-1-yl)-phenyl]-5-hydroxymethyl}-oxazolidin-2-one 

Relevant articles and documents

Alternative reaction medium for the synthesis of 1-propargylpyrazoles

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Ferrocene burning rate catalyst containing bis (imidazole or pyrazole-1, 2, 3-triazole) group and preparation method thereof

The invention discloses a ferrocene burning rate catalyst containing a bis (imidazole or pyrazole-1, 2, 3-triazole) group and a preparation method thereof, the structural formula of the burning rate catalyst is shown in the specification, R1 and R2 independently represent-C or-N, R represents-H or-NO2, and R1 and R2 are different. According to the invention, more nitrogen atoms are introduced into the ferrocene burning rate catalyst, so that hydrogen bonds are easily formed in molecules, and the compounds are not easy to migrate and volatilize under natural conditions and have good thermal stability. As the nitrogen-rich group has high formation heat and combustion heat, the ferrocene burning rate catalyst can improve the energy level of a solid propellant when being used in the solid propellant, and has a good combustion catalysis effect on main components, namely ammonium perchlorate and hexogen, of the solid propellant. Theburning rate catalyst is synthesized by adopting a click reaction method, the preparation method is simple to operate and low in synthesis cost, and the defects of complex synthesis process, high price, high cost and the like of the existing ferrocene and derivatives thereof are overcome.

Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions

To identity fast-acting, multistage antimalarial agents, a series of pyridylvinylquinoline-triazole analogues have been synthesized via CuAAC. Most of the compounds display significant inhibitory effect on the drug-resistant malarial Dd2 strain at low submicromolar concentrations. Among the tested analogues, compound 60 is the most potent molecule with an EC50 value of 0.04 ± 0.01 μM. Our current study indicates that compound 60 is a fast-acting antimalarial compound and it demonstrates stage specific action at the trophozoite phase in the P. falciparum asexual life cycle. In addition, compound 60 is active against both early and late stage P. falciparum gametocytes. From a mechanistic perspective, compound 60 shows good activity as an inhibitor of β-hematin formation. Collectively, our findings suggest that fast-acting agent 60 targets dual life stages of the malarial parasites and warrant further investigation of pyridylvinylquinoline hybrids as new antimalarials.