1629048-13-0

Basic information

• Product Name: C₂₇H₂₇N₅O₅
• Synonyms: C₂₇H₂₇N₅O₅
• CAS NO: 1629048-13-0
• Molecular Weight: 501.542
• Mol File: 1629048-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₇N₅O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₇N₅O₅(1629048-13-0)
• EPA Substance Registry System: C₂₇H₂₇N₅O₅(1629048-13-0)

Safety Data

• Hazardous Substances Data: 1629048-13-0(Hazardous Substances Data)

Upstream product

• 20306-74-5 1-(prop-2-yn-1-yl)-1H-pyrazole 
• 234106-08-2 (2R,3S)-5β-azido-2-{[(4-methylbenzoyl)oxy]methyl}tetrahydrofuran-3-yl 4-methylbenzoate 

Downstream Products

• 1629048-20-9 C₃₂H₃₃N₅O₅ 
• 1629048-23-2 C₄₁H₅₀N₇O₆P 

Relevant articles and documents

A family of click nucleosides for metal-mediated base pairing: Unravelling the principles of highly stabilizing metal-mediated base pairs

A family of artificial nucleosides has been developed by applying the CuI-catalyzed Huisgen 1,3-dipolar cycloaddition. Starting from 2-deoxy-β-D-glycosyl azide as a common precursor, three bidentate nucleosides have been synthesized. The 1,2,3-triazole involved in all three nucleobases is complemented by 1,2,4-triazole (TriTri), pyrazole (TriPyr), or pyridine (TriPy). Molecular structures of two metal complexes indicate that metal-mediated base pairs of TriPyr may not be fully planar. An investigation of DNA oligonucleotide duplexes comprising the new click nucleosides showed that they can bind AgI to form metal-mediated base pairs. In particular the mispair formed from TriPy and the previously established imidazole nucleoside is significantly stabilized in the presence of Ag I. A comparison of different oligonucleotide sequences allowed the determination of general factors involved in the stabilization of nucleic acids duplexes with metal-mediated base pairs. Artificial base pairs: The application of three closely related triazole-derived artificial nucleosides in metal-mediated base pairing is described (see figure). Depending on the complementary nucleoside, [2+2] and [2+1] coordination modes are possible. The investigation of different oligonucleotide sequences has enabled the derivation of general principles underlying the formation of highly stabilizing metal-mediated base pairs.