203117-74-2Relevant academic research and scientific papers
B-Ring unsaturated estrogens: Biological evaluation of 17α- Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens
Lugar III, Charles W.,Magee, David,Adrian, Mary D.,Shetler, Pamela,Bryant, Henry U.,Dodge, Jeffrey A.
, p. 4281 - 4284 (2003)
The pharmacology and SAR of representative equine estogens is described. 17α-Dihydroequilenin was found to prevent bone loss after 5 weeks of oral administration to ovariectomized rats. The stereochemical significance of the D-ring and the C/D ring junctu
8-substituted B-nor-6-Thiaequilenin compounds having activity as selective estrogen receptor modulators
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, (2008/06/13)
Certain B-nor-6-thiaequilenin compounds substituted at the 3-position with hydroxy and at the 8-position with hydroxy or alkoxy of from one to four carbon atoms are selective estrogen receptor modulators and are useful in the treatment of estrogen-related disorders including such conditions as osteoporosis, hyperlipidemia, estrogen-dependent breast cancer, uterine fibrosis, endometriosis, and restenosis.
