203186-58-7

Usage

Uses

1. Used in Pharmaceutical Synthesis:
Ethyl(E)-2-((dimethylamino)methylene)-3-oxobutanoate is used as a key intermediate for the synthesis of N-substituted-[1,2,4]triazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines. These compounds exhibit significant antibacterial activity, making them valuable in the development of new antibiotics to combat bacterial infections.
2. Used in Chemical Research:
Due to its unique structure and reactivity, ethyl(E)-2-((dimethylamino)methylene)-3-oxobutanoate can be employed in various chemical research applications. It can be used to explore new reaction pathways, develop novel synthetic methods, and create innovative molecules with potential applications in various industries, such as materials science, agrochemistry, and environmental science.
3. Used in Drug Design and Development:
The compound's ability to form N-substituted-[1,2,4]triazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines with antibacterial properties makes it a promising candidate for drug design and development. Researchers can use ethyl(E)-2-((dimethylamino)methylene)-3-oxobutanoate as a starting material to design and synthesize new drugs with improved efficacy, selectivity, and safety profiles.

Upstream product

• 64872-97-5 ethyl 2-(1,3-dithian-2-yl)-3-oxobutanoate 
• 124-40-3 dimethyl amine 
• 141-97-9 ethyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1410084-58-0 5-(5-Methyl-1-phenyl-1H-4-pyrazolyl)-3-[(4-nitroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-60-4 3-[(4-Methoxyanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-66-0 5-(5-Methyl-1-phenyl-1H-4-pyrazolyl)-3-[2-(trifluoromethyl)anilino]methyl-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-69-3 3-[(2,5-Difluoroanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 204260-39-9 5-methyl-1-phenyl-1H-4-pyrazolecarbohydrazide 
• 816429-52-4 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide 
• 1410084-41-1 3-(Anilinomethyl)-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-44-4 3-[(4-Fluoroanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-46-6 3-[(2-Chloroanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-48-8 3-[(4-Chloroanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3, 4-oxadiazole-2-thione 
• 1410084-53-5 3-[(4-Bromoanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1410084-56-8 5-(5-Methyl-1-phenyl-1H-4-pyrazolyl)-3-[(3-nitroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 89193-16-8 ethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate 
• 1266331-58-1 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide 

Relevant academic research and scientific papers

WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE

Compounds and compositions are provided as inhibitors of the Wnt/β-catenin pathway for the treatment of diseases that implicate the same.

Synthesis and antimicrobial activity of linked heterocyclics containing pyrazole and oxadiazoles

A new series of 3-(arylaminomethyl)-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2, 3-dihydro-1,3,4-oxadiazole-2-thiones 6a-j has been synthesized by the reaction of 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-ylhydrosulfide 5 with formaldehyde and corresponding anilines. The chemical structures of newly synthesized compounds were elucidated by IR, 1H, 13C-NMR, MS, and elemental analyses. The compounds 6a-j were evaluated for their antibacterial activity against three representative Gram positive bacteria viz. Bacillus subtilis (MTCC 441), Bacillus sphaericus (MTCC 11) and Staphylococcus aureus (MTCC 96), and three Gram negative bacteria viz. Pseudomonas aeruginosa (MTCC 741), Klobsinella aerogenes (MTCC 39) and Chromobacterium violaceum. Among the screened 6b, 6d, 6i, and 6j in which oxadiazole moiety bearing 4-fluoroanilinomethyl, 4-chloroanilinomethyl, 2-trifluoromethylanilinomethyl, and 2,5-difluoroanilinomethyl groups, respectively, showed high activity against all the microorganisms used. In addition these compounds were also screened for their antifungal activity against four fungal organisms viz. Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), and Trichophyton mentagrophytes (IFO 40996). Most of these new compounds showed appreciable activity against test fungi, and emerged as potential molecules for further development.

Iron-catalyzed aminolysis of β-carbonyl 1,3-dithianes: Synthesis of stereodefined β-enaminones and 3,4-disubstituted pyrazoles

A novel iron-catalyzed aminolysis of β-carbonyl 1,3-dithianes with various amines including ammonia, primary and secondary amines, as well as hydrazine hydrate has been developed, leading to the synthesis of stereodefined β-enaminones and 3,4-disubstitute