203188-95-8Relevant academic research and scientific papers
Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics
Petitou, Maurice,Driguez, Pierre-Alexandre,Duchaussoy, Philippe,Herault, Jean-Pascal,Lormeau, Jean-Claude,Herbert, Jean-Marc
, p. 1161 - 1166 (2007/10/03)
A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylareal hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.
