226069-56-3Relevant academic research and scientific papers
GLYCOSAMINOGLYCAN (GAG) MIMETICS
-
Page/Page column 20-21, (2010/02/12)
The invention relates to compounds that are designed to mimic the structure of GAGs; methods for the preparation of the compounds; compositions comprising the compounds; and use of the compounds and compositions thereof for the anti-angiogenic, anti-metas
Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics
Petitou, Maurice,Driguez, Pierre-Alexandre,Duchaussoy, Philippe,Herault, Jean-Pascal,Lormeau, Jean-Claude,Herbert, Jean-Marc
, p. 1161 - 1166 (2007/10/03)
A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylareal hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.
