2032-75-9

Usage

Uses

Used in Chemical Industry:
2,2-Dichloro-1,3-benzodioxole is used as a chemical intermediate for the synthesis of other chemicals. Its unique structure allows it to be a versatile building block in the production of various compounds.
Used in Pharmaceutical Industry:
2,2-Dichloro-1,3-benzodioxole is used as a key component in the preparation of pharmaceuticals. Its presence in drug molecules can contribute to their therapeutic properties, making it an essential part of the development process for new medications.

InChI:InChI=1/C7H4Cl2O2/c8-7(9)10-5-3-1-2-4-6(5)11-7/h1-4H

Upstream product

• 274-09-9 Methylenedioxybenzene 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 123-19-3 4-heptanone 
• 110614-21-6 3-Chloro-3-phenyl-propionic acid 2-hydroxy-phenyl ester 
• 110637-28-0 2,2-Bis-(2-chloro-2-phenyl-ethyl)-benzo[1,3]dioxole 
• 108-83-8 diisobutyl ketone 
• 110614-23-8 2-Chloro-2-methyl-cyclohexanecarboxylic acid 2-hydroxy-phenyl ester 
• 110614-16-9 2-[2-(2-Oxo-2-phenyl-ethyl)-benzo[1,3]dioxol-2-yl]-1-phenyl-ethanone 
• 110614-19-2 3-Chloro-2,3-dimethyl-butyric acid 2-hydroxy-phenyl ester 
• 110614-35-2 2,2,3-Trimethyl-but-3-enoic acid 2-hydroxy-phenyl ester 
• 110614-20-5 3-Chloro-2,2,3-trimethyl-butyric acid 2-hydroxy-phenyl ester 
• 96-22-0 pentan-3-one 
• 502-56-7 nonanone-5 
• 110614-22-7 2-Chloro-2-methyl-cyclopentanecarboxylic acid 2-hydroxy-phenyl ester 
• 110614-24-9 (1R,4S)-3-Chloro-bicyclo[2.2.1]heptane-2-carboxylic acid 2-hydroxy-phenyl ester 
• 110614-25-0 ((1R,4S)-2-Chloro-3,3-dimethyl-bicyclo[2.2.1]hept-2-yl)-acetic acid 2-hydroxy-phenyl ester 

Relevant academic research and scientific papers

Ortho-spirocarbonates and ortho-spirothiocarbonates: synthesis, functionalization and coupling

This paper describes a new efficient synthesis of 2,2′-spirobi-(1,3-benzoxathiole) (1), 2,2′-spirobi-(1,3-benzodithiole) (2) and 2,2′-spirobi-(1,3-benzodioxole) (3). Compound 3 has been functionalized by means of metallation reaction followed by electrophilic quenching to give carboxylic acids, aldehydes and alcohols. Furthermore compound 3 was subjected to homo-coupling and its dimeric structure was determined by XRD analysis.

PROCESS FOR THE PREPARATION OF 2,2-DIFLUORO-1,3-BENZODIOXOLE AND INTERMEDIATES THEREOF

The present invention relates to a process for preparing 2,2-difluoro-1,3-benzodioxole. The process comprises a step of reacting 1,3-benzodioxole with chlorine in benzotrifluoride in the present of a radical initiator. The present invention also relates to the process for preparing 2,2-dichloro-1,3-benzodioxole which is used as an intermediate in preparation of 2,2-difluoro-1,3-benzodioxole.

A Traceless Tether Strategy for Achieving Formal Intermolecular Hexadehydro-Diels-Alder Reactions

A synthetic strategy formally equivalent to an intermolecular hexadehydro-Diels-Alder (HDDA) reaction is described. Sulfur-based linkers were designed and constructed by joining terminal alkynes or diynes using alkyne thiolate chemistry. The resulting tetraynes and triynes successfully underwent HDDA cyclization and benzyne trapping. Linker removal by reductive desulfurization was uneventful. The strategy was also found suitable for the tetradehydro-Diels-Alder (TDDA) reaction.

PROCESS FOR THE PREPARATION OF DERIVATIVES OF BENZODIOXOLE

The present invention relates to the process for preparing compounds of Formula I, Formula III and Formula V.

One-pot preparation method of 2,2-difluoro-1,3-benzodioxole

The invention relates to a one-pot preparation method of 2,2-difluoro-1,3-benzodioxole. The one-pot preparation method of 2,2-difluoro-1,3-benzodioxole is characterized by comprising the following steps: adding piperonyl cyclonene, phosphorus oxychloride and phosphorus pentachloride in a lined polytetrafluoroethylene stainless steel bottle, rising temperature to reflux, ending the reaction when the content of piperonyl cyclonene taken as a raw material is detected to be less than 0.2% by GC, carrying out vacuum rectification on a reaction solution to distill off phosphorus trichloride which is a byproduct and phosphorus oxychloride taken as a solvent; cooling to the temperature of 0 to 5 DEG C after the vacuum rectification is finished, dropwise adding hydrogen fluoride liquid at the vacuum degree of minus 0.1 to minus 0.09MPa, then carrying out heat preservation and releasing the byproduct, namely hydrogen chloride; then dropwise adding a saturated sodium carbonate aqueous solution, adjusting the PH value of the solution to be 6.5 to 7.5, stirring and standing to be stratified, taking an organic layer and distilling to obtain a finished product, namely 2,2-difluoro-1,3-benzodioxole which is colorless and transparent liquid. The one-pot preparation method of 2,2-difluoro-1,3-benzodioxole disclosed by the invention has the advantages of low reaction temperature, high safety and improved yield.

Bis(zinc porphyrin) bridged by benzo orthocarbonates as a conformational switch under regulation of DABCO and a Cu+ Ion

A tweezer-type bis(zinc porphyrin) bridged by benzo orthocarbonates was synthesized and applied as a molecular conformational switch under regulation of DABCO and a Cu+ ion. The switch property has been confirmed by 1H NMR, UV-vis sp

Process for fluorurating ethers

The invention relates to a new process of fluorination of aromatic ethers in the alpha position on the side chain, passing through the corresponding chlorinated derivative without isolation thereof, in a dichloro-benzotrifluoride as solvent.

Halogenation processes in advantageous solvents, and novel bistrifluoromethyl-polyfluoroalkoxybenzenes

Compounds such as STR1 wherein R is F, CF3, CF2 H, CHF CF3 or CF2 CF3, as well as related compounds containing chlorine, are used as solvents in halogenation processes.

Process for the α-chlorination of aryl ethers

Aryl ethers are chlorinated in the α-position by a process in which they are metered into a reaction vessel at the same time as chlorine, the reaction being carried out at temperatures in the range from 60° to 150° C.

Benzoheterocyclyl ketone hydrazone insecticides

Benzoheterocyclyl ketone hydrazones of the formula STR1 in which Y is methylene, difluoromethylene or oxygen and n is 0 or 1, compositions thereof and their use as insecticides are disclosed and exemplified.