20323-75-5Relevant academic research and scientific papers
A Facile Total Synthesis of Isoquinolone Alkaloids
Lee, Albert, W. M.,Chan, Wing Hong,Chan, Eddy T. T.
, p. 309 - 310 (2007/10/02)
Four isoquinolone alkaloids, N-methylcorydaldine 8a, oxyhydrastinine 8b, 6,7-dimethoxy-2-methylisocarbostyril 9a and doryanine 9b, have been efficiently synthesized from phenyl vinyl sulfoxide via the Pummerer type rearrangement as a key step.
FREMY'S SALT OXIDATION OF SOME ISOQUINOLINE ALKALOIDS. BIOGENETIC CONSIDERATIONS
Castedo, Luis,Puga, Alberto,Saa, Jose M.,Suau, Rafael
, p. 2233 - 2236 (2007/10/02)
Fremy's salt oxidation of benzylisoquinoline and aporphine alkaloids to isoquinolones and oxoaporphines is described.Aminium radicals are suggested to account for the observed results.Their possible involvement in alkaloid biosynthesis is considered.
Synthesis of 6,7-Dimethoxyisoquinolones and of 6,7-Dimethoxy-2-methyl-1(2H)-isoquinolone, an Alkaloid of Hernandia ovigera
Modi, A. R.,Tirodkar, R. B.,Usgaonkar, R. N.
, p. 813 - 815 (2007/10/02)
3-Methyl, 3-formyl, 3-carboxy- and 3-hydroxymethyl-6,7-dimethoxy-1(2H)-isoquinolones (Ia-IVa) and their N-methyl (Ib-IVb) derivatives have been synthesized starting from 6,7-dimethoxyhomophthalic acid.Decarboxylation of 3-carboxyisoquinolones furnishes the corresponding isoquinolones and thus provide a new synthesis for the natural alkaloid, 6,7-dimethoxy-2-methyl-1(2H)-isoquinolone (Vb). β-- and 6β--acrylic acvids (VIa,b) have also been synthesized.
