20323-75-5

Usage

Class

Isoquinoline derivative

Physical state

White solid

Molecular weight

221.25 g/mol

Pharmaceutical research and drug development use

Common

Potential medicinal properties

Anti-inflammatory, anti-cancer, neuroprotective, antioxidant, and analgesic

Ongoing research

Investigating potential therapeutic applications and chemical properties.

Upstream product

• 2679-26-7 2-Methylpapaverinium iodide 
• 1699-51-0 laudanosine 
• 16620-92-1 14-nitro-N-methylpapaverinium iodide 
• 5653-42-9 3,4-dimethoxyhomophthalic anhydride 
• 140848-61-9 Acetic acid 2-[(3,4-dimethoxy-benzoyl)-methyl-amino]-1-phenylsulfanyl-ethyl ester 
• 3947-79-3 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium iodide 

Downstream Products

• 5833-04-5 1-Benzyl-6,7-dimethoxy-2-methyl-isochinolinium; Jodid 

Relevant academic research and scientific papers

A Facile Total Synthesis of Isoquinolone Alkaloids

Four isoquinolone alkaloids, N-methylcorydaldine 8a, oxyhydrastinine 8b, 6,7-dimethoxy-2-methylisocarbostyril 9a and doryanine 9b, have been efficiently synthesized from phenyl vinyl sulfoxide via the Pummerer type rearrangement as a key step.

Synthesis of 6,7-Dimethoxyisoquinolones and of 6,7-Dimethoxy-2-methyl-1(2H)-isoquinolone, an Alkaloid of Hernandia ovigera

3-Methyl, 3-formyl, 3-carboxy- and 3-hydroxymethyl-6,7-dimethoxy-1(2H)-isoquinolones (Ia-IVa) and their N-methyl (Ib-IVb) derivatives have been synthesized starting from 6,7-dimethoxyhomophthalic acid.Decarboxylation of 3-carboxyisoquinolones furnishes the corresponding isoquinolones and thus provide a new synthesis for the natural alkaloid, 6,7-dimethoxy-2-methyl-1(2H)-isoquinolone (Vb). β-- and 6β--acrylic acvids (VIa,b) have also been synthesized.

FREMY'S SALT OXIDATION OF SOME ISOQUINOLINE ALKALOIDS. BIOGENETIC CONSIDERATIONS

Fremy's salt oxidation of benzylisoquinoline and aporphine alkaloids to isoquinolones and oxoaporphines is described.Aminium radicals are suggested to account for the observed results.Their possible involvement in alkaloid biosynthesis is considered.