20324-66-7Relevant academic research and scientific papers
Preparation method and application of 4-hydroxyemodin
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, (2020/04/29)
The invention belongs to the technical field of medicines, and relates to a preparation method and application of 4-hydroxyemodin, in particular to a preparation method of 4-hydroxyemodin and application of 4-hydroxyemodin, optical isomers, pharmaceutical
Anthraquinone glycoside from stem bark, fatty acids and sterols from seeds of Cassia reingera
Ledwani, Lalita,Singh, Mukhtar
, p. 1970 - 1971 (2007/10/03)
From the bark of Cassia reingera 1,5,6-trihydroxy-3-methylanthraquinone-8- O-α-L-glucoside has been isolated and its structure elucidated with the help of chemical studies and spectral data. The dyeing property of crude anthraquinone has been studied to d
The Chemical Structure and the Mutagenicity of Emodin Metabolites
Morooka, Nobuhisa,Nakano, Sonoko,Itoi, Noriko,Ueno, Yoshio
, p. 1247 - 1252 (2007/10/02)
Emodin (1,3,8-trihydroxy-6-methyl-9,10-anthraquinone) is a natural occuring anthraquinone formed in rhubarb and fungal metabolites.Emodin was transformed into 6 major metabolites by rat hepatic microsomes.The metabolites were identified as 2-hydroxyemodin, 4-hydroxyemodin, 5-hydroxyemodin, 7-hydroxyemodin, ω-hydroxyemodin, and emodic acid by comparison with the synthetic compounds using thin-layer chromatography.It was clear that 2-hydroxyemodin is a proximate mutagen as a synthetic compound by the Salmonella assay.Other metabolites, such as 5-hydroxyemodin and ω-hydroxyemodin, became active after metabolic activation, but 4-hydroxyemodin and emodic acid were inactive either in the presence or in the absence of the metabolic activation system.
