203246-71-3

Basic information

• Product Name: Tetrahydro-pyran-4-thiol
• Synonyms: Tetrahydro-pyran-4-thiol;tetrahydro-2H-pyran-4-thiol;2H-Pyran-4-thiol, tetrahydro-
• CAS NO: 203246-71-3
• Molecular Formula: C5H10OS
• Molecular Weight: 118.1973
• Mol File: 203246-71-3.mol

Chemical Properties

• Boiling Point: 174.8°C at 760 mmHg
• Flash Point: 59.5°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 1.59mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: Tetrahydro-pyran-4-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-pyran-4-thiol(203246-71-3)
• EPA Substance Registry System: Tetrahydro-pyran-4-thiol(203246-71-3)

Safety Data

• Hazardous Substances Data: 203246-71-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tetrahydro-pyran-4-thiol is used as a building block for the development of various pharmaceutical goods, particularly for the synthesis of MDM2 inhibitors. These inhibitors play a crucial role in the treatment of cancer by targeting the MDM2 protein, which is often overexpressed in various types of cancer cells, leading to the disruption of the p53 tumor suppressor pathway. By inhibiting MDM2, these drugs can potentially restore the function of the p53 protein, thereby promoting apoptosis and inhibiting tumor growth.

InChI:InChI=1/C5H10OS/c7-5-1-3-6-4-2-5/h5,7H,1-4H2

Upstream product

• 25637-16-5 4-bromotetrahydro-2H-pyran 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 203246-70-2 thioacetic acid S-(tetrahydro-pyran-4-yl)ester 

Downstream Products

• 1453173-84-6 N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide 
• 1272855-55-6 4-(tetrahydropyran-4-ylsulfanyl)benzonitrile 
• 1335140-20-9 4-[(3-bromo-5-methylphenyl)sulfonyl]tetrahydro-2H-pyran 

Relevant articles and documents

Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation

A nickel-catalyzed aryl thioether metathesis has been developed to access high-value thioethers. 1,2-Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional-group-tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis that does not involve alkene bonds. In-depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single-bond metathesis reactions.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.