203246-71-3

Basic information

• Product Name: Tetrahydro-pyran-4-thiol
• Synonyms: Tetrahydro-pyran-4-thiol;tetrahydro-2H-pyran-4-thiol;2H-Pyran-4-thiol, tetrahydro-
• CAS NO: 203246-71-3
• Molecular Formula: C5H10OS
• Molecular Weight: 118.1973
• Mol File: 203246-71-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 174.8°C at 760 mmHg
• Flash Point: 59.5°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 1.59mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: Tetrahydro-pyran-4-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-pyran-4-thiol(203246-71-3)
• EPA Substance Registry System: Tetrahydro-pyran-4-thiol(203246-71-3)

Safety Data

• Hazardous Substances Data: 203246-71-3(Hazardous Substances Data)

Usage

Uses

Tetrahydropyran-4-thiol is a building block for various pharmaceutical goods such as MDM2 inhibitors for the treatment of cancer.

InChI:InChI=1/C5H10OS/c7-5-1-3-6-4-2-5/h5,7H,1-4H2

Upstream product

• 25637-16-5 4-bromotetrahydro-2H-pyran 
• 203246-70-2 thioacetic acid S-(tetrahydro-pyran-4-yl)ester 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 

Downstream Products

• 1453173-84-6 N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide 
• 1272855-55-6 4-(tetrahydropyran-4-ylsulfanyl)benzonitrile 
• 1335140-20-9 4-[(3-bromo-5-methylphenyl)sulfonyl]tetrahydro-2H-pyran 

Relevant articles and documents

Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation

A nickel-catalyzed aryl thioether metathesis has been developed to access high-value thioethers. 1,2-Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional-group-tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis that does not involve alkene bonds. In-depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single-bond metathesis reactions.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.