203258-44-0

Basic information

• Product Name: 2-(2-AMINOETHYL)-1 3-DI-BOC-GUANIDINE
• Synonyms: Propanoylchloride,4-methoxy-;2-(2-Aminoethyl)-1,3-di-Boc-guanidine technical, >=90% (HPLC);Carbamicacid,N,N'-[(2-aminoethyl)carbonimidoyl]bis-,bis(1,1-dimethylethyl)ester;Carbamic acid, N,N'-[(2-aminoethyl)carbonimidoyl]bis-, C,C'-bis(1,1-dimethylethyl) ester;tert-butyl [N'-(2-aminoethyl)-N-(tert-butoxycarbonyl)carbamimidoyl]carbamate (non-preferred name)
• CAS NO: 203258-44-0
• Molecular Formula: C₁₃H₂₆N₄O₄
• Molecular Weight: 302.37
• Mol File: 203258-44-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 95-98 °C
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• PKA: 7.01±0.46(Predicted)
• CAS DataBase Reference: 2-(2-AMINOETHYL)-1 3-DI-BOC-GUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-AMINOETHYL)-1 3-DI-BOC-GUANIDINE(203258-44-0)
• EPA Substance Registry System: 2-(2-AMINOETHYL)-1 3-DI-BOC-GUANIDINE(203258-44-0)

Safety Data

• WGK Germany: 3
• F: 10-34
• Hazardous Substances Data: 203258-44-0(Hazardous Substances Data)

Usage

General Description

2-(2-aminoethyl)-1,3-di-BOC-guanidine is a chemical compound that features a guanidine functional group, which consists of a central carbon atom doubly bonded to a nitrogen atom and singly bonded to three amino groups. The compound is also modified with BOC (tert-butoxycarbonyl) protecting groups, which help to shield reactive functional groups during chemical reactions. 2-(2-AMINOETHYL)-1 3-DI-BOC-GUANIDINE is often used in organic chemistry as a reagent for various synthetic transformations, especially in the preparation of biologically active molecules and pharmaceuticals. Its guanidine moiety gives it basic properties, making it useful in the synthesis of guanidine-containing compounds and polymers. Additionally, the presence of the aminoethyl group allows for potential interactions with biological targets, making it of interest for medicinal chemistry research.

Upstream product

• 145013-05-4 tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate 
• 107-15-3 ethylenediamine 
• 322474-21-5 N,N'-bis-Boc-S-methyl-isothiourea 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 207857-15-6 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine 

Downstream Products

• 344779-93-7 C₅₉H₇₉N₇O₂₁ 
• 1610839-77-4 tert-butyl-1-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)-10,10-dimethyl-1,8-dioxo-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate 
• 215050-19-4 C₃₇H₄₉N₇O₁₁S 
• 215050-16-1 C₃₃H₄₇N₇O₁₁S 

Relevant articles and documents

Modification of Biphenolic Anti-Bacterial to Achieve Broad-Spectrum Activity

The Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria, Acinetobacter baumannii, are pathogens responsible for millions of nosocomial infections worldwide. Due to the threat of bacteria evolving resistance to antibiotics, scientists are constantly looking for new classes of compounds to treat infectious diseases. The biphenolic analogs of honokiol that were most potent against oral bacteria had similar bioactivity against MRSA. However, all the compounds proved ineffective against A. baumannii. The inability to inhibit A. baumannii is due to the difficult-to-penetrate lipopolysaccharide-coated outer membrane that makes it challenging for antibiotics to enter Gram-negative bacteria. The C 2 scaffold was optimized from the inhibition of Gram-positive bacteria to broad-spectrum antibacterial compounds that inhibit the dangerous Gram-negative pathogen A. baumannii.

The synthesis and glycosidase inhibitory activity of analogues of tiruchanduramine

Five analogues (7a-e) of the metabolite tiruchanduramine 1 were prepared. Compounds 7d and 7e were specific inhibitors of yeast α-glucosidase, whilst 7e specifically inhibited Bacillus α-glucosidase. Compounds 7b and 7c were the best inhibitors of β-gluco

Dimeric indole alkaloid compounds, preparation method thereof and use thereof in preparation of antibacterial drugs

The present invention belongs to the fields of organic synthesis and pharmaceutical chemistry. In particular, the present invention relates to a series of dimeric indole alkaloid compounds as shown instructural general formula I, a preparation method thereof and use thereof in preparation of antibacterial drugs. After in vitro activity screening, results show that the compounds have strong antibacterial activity, in particular have specific inhibitory effects on strains of gram-positive bacteria such as staphylococcus, bacillus and enterococcus, and related drug-resistant strains thereof, andcan be used as lead compounds for developing new antibacterial drugs.