203258-88-2

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 203631-00-9 (R)-2-Phenyl-2-((R)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol 
• 203630-99-3 (R)-2-Phenyl-2-((S)-1-phenyl-1-trifluoromethyl-allylamino)-ethanol 
• 203630-97-1 (R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-methyl-1-phenyl-ethylamino)-ethanol 

Relevant academic research and scientific papers

Stereospecific reduction with retention of chiral fluoral-derived 1,3-oxazolidines with LiAlH4 : Asymmetric synthesis of 1-substituted 2,2,2-trifluoroethylamines

The asymmetric synthesis of 1-substituted 2,2,2-trifluoroethylamines from chiral 1,3-oxazolidines having trifluoromethyl group derived from trifluoromethyl ketones and (R)-phenylglycinol is described. The stereospecific reduction of chiral 1,3-oxazolidines with LiAlH4 proceeds in retention fashion.

Stereocontrol at the quaternary center in 1-substituted 1-phenyl-2,2,2-trifluoroethylamines: Stereospecific substitution with retention of a chiral cyclic fluoral N,O-acetal with organolithium reagents

The asymmetric synthesis of 1-substituted 1-phenyl-2,2,2-trifluoroethylamines from chiral 1,3-oxazolidines is described. The stereospecific substitution reaction with organolithium reagents of chiral 1,3-oxazolidines having a trifluoromethyl group proceeds with retention to control the newly created quaternary center.