20326-12-9Relevant academic research and scientific papers
Substituted 4 phenyl 1 (3 pyrazolyl alkyl) piperazines. II. Synthesis of 3 pyrazolyl ethylamines
Poetsch,Koppe
, p. 162 - 170 (2007/10/05)
Using the tranquilizer mepiprazol (a pyrazolyl 3 ethylamine derivative) as an example, the paper describes a new synthesis of this class of substances starting from appropriately modified β dicarbonyl compounds, the preparation and chemical behavior of which are investigated. The transferability of this method to further pyrazolyl 3 ethylamine derivatives is demonstrated on the basis of some examples. The important intermediate stage for the mechanism of pyrazole cyclisation to these derivatives is taken to be the corresponding enhydrazinoketone.
