2033-83-2Relevant academic research and scientific papers
A pillar[5]arene-based cyanide sensor bearing on a novel cyanide-induced self-assemble mechanism
Cheng, Xiaobin,Li, Hui,Zheng, Feng,Lin, Qi,Zhang, Youming,Yao, Hong,Wei, Taibao
, p. 59 - 66 (2016)
We have designed and synthesized a novel copillar[5]arene-based chemosensor, which employ 8-hydroxyquinoline group as a binding site and signal group. By a novel cyanide-induced self-assemble mechanism, the pillar[5]arene-based chemosensor shown high sens
Photoresponsive supramolecular self-assembly of monofunctionalized pillar[5]arene based on stiff stilbene
Wang, Yuan,Xu, Jiang-Fei,Chen, Yu-Zhe,Niu, Li-Ya,Wu, Li-Zhu,Tung, Chen-Ho,Yang, Qing-Zheng
, p. 7001 - 7003 (2014)
We report a photoresponsive monofunctionalized pillar[5]arene based on stiff stilbene. The Z isomer, Z-1, tends to form self-complexing [1]pseudorotaxanes and [c2] daisy chains, whereas the E analog, E-1, forms supramolecular polymers. the Partner Organis
Stimuli-responsive supramolecular polymer network based on bi-pillar[5]arene for efficient adsorption of multiple organic dye contaminants
Wei, Tai-Bao,Qi, Li-Hua,Zhang, Qin-Peng,Zhang, Wen-Huan,Yao, Hong,Zhang, You-Ming,Lin, Qi
, p. 12531 - 12537 (2020)
A novel supramolecular polymer network gel (NT), based on bi-pillar[5]arene, which can adsorb and separate organic dyes, has been efficiently constructed. First, a novel supramolecular gelator, NBP5 (host), and a tripodal guest, TG (guest), were successfu
A stretchable pillararene-containing supramolecular polymeric material with self-healing property
Chen, Jianzhuang,Han, Huijing,Li, Changjun,Liao, Xiaojuan,Shan, Xiaotao,Xie, Meiran,Zhao, Meng,Zhao, Qiuhua
supporting information, (2021/05/25)
Constructing polymeric materials with stretchable and self-healing properties arise increasing interest in the field of tissue engineering, wearable electronics and soft actuators. Herein, a new type of supramolecular cross-linker was constructed through
Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy
Chen, Zelong,Hu, Xianjun,Jin, Ming,Pei, Yuxin,Pei, Zhichao,Pu, Liang,Wang, Yang
supporting information, p. 10642 - 10645 (2020/10/02)
Supramolecular glyco-nanovesicles (SeSe-(P5)2?Man-NH3+) based on the host-guest complex of a diselenium-bridged pillar[5]arene dimer and a mannose derivative have been successfully developed for the first time, which possessed tumor microenvironment-respo
Dual-Stimuli-Responsive Fluorescent Supramolecular Polymer Based on a Diselenium-Bridged Pillar[5]arene Dimer and an AIE-Active Tetraphenylethylene Guest
Wang, Yan,Lv, Ming-Zhe,Song, Nan,Liu, Zeng-Jie,Wang, Chunyu,Yang, Ying-Wei
, p. 5759 - 5766 (2017/08/14)
We report a new strategy to construct a multi-stimuli-responsive fluorescent supramolecular polymer by the strong host-guest interactions between a diselenium bond-bridged pillar[5]arene dimer and an AIE-active tetraphenylethylene (TPE)-containing neutral
Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX
Chambers, Janice E.,Chambers, Howard W.,Funck, Kristen E.,Meek, Edward C.,Pringle, Ronald B.,Ross, Matthew K.
, p. 154 - 159 (2016/12/06)
Pyridinium oximes are strong nucleophiles and many are effective reactivators of organophosphate-inhibited cholinesterase (ChE). However, the current oxime reactivators are ineffective at crossing the blood-brain barrier and reactivating brain ChE in the intact organism. Our laboratories have developed a series of substituted phenoxyalkyl pyridinium oximes (US patent 9,227,937 B2) with the goal of identifying reactivators effective in crossing the blood-brain barrier. The first 35 of the series were found to have similar in?vitro efficacy as reactivators of ChE inhibited by a sarin surrogate (phthalimidyl isopropyl methylphosphonate, PIMP) or a VX surrogate (nitrophenyl ethyl methylphosphonate, NEMP) in bovine brain preparations as previously observed in rat brain preparations. A number of these novel oximes have shown the ability to decrease the level of ChE inhibition in the brains of rats treated with a high sublethal dosage of either a sarin surrogate (nitrophenyl isopropyl methylphosphonate, NIMP) or the VX surrogate NEMP. Levels of reactivation at 2?h after oxime administration were up to 35% while the currently approved therapeutic, 2-PAM, yielded no reduction in brain ChE inhibition. In addition, there was evidence of attenuation of seizure-like behavior with several of the more effective novel oximes, but not 2-PAM. Therefore these novel oximes have demonstrated an ability to reactivate inhibited ChE in brain preparations from two species and in?vivo data support their ability to enter the brain and provide a therapeutic action. These novel oximes have the potential to be developed into improved antidotes for nerve agent therapy.
Synthesis and cytotoxicity of 2,3-enopyranosyl C-linked conjugates of genistein
Szeja, Wieslaw,Grynkiewicz, Grzegorz,Bieg, Tadeusz,Swierk, Piotr,Byczek, Anna,Papaj, Katarzyna,Kitel, Radoslaw,Rusin, Aleksandra
, p. 7072 - 7093 (2014/07/08)
A series of glycoconjugates, derivatives of genistein containing a C-glycosylated carbohydrate moiety, were synthesized and their anticancer activity was tested in vitro in the human cell lines HCT 116 and DU 145. The target compounds 15-17 were synthesiz
Synthesis of N-aryloxyalkylanabasine derivatives
Slyn'Ko,Tatarova,Shakirov,Shul'Ts
, p. 294 - 301 (2013/07/26)
N-Aryloxyalkylanabasine derivatives were prepared via the reaction of anabasine hydrochloride with various aryloxyhaloalkanes in the presence of potash in DMF. The reaction occurred with retention of the chiral center C-(2) of the piperidine group. Side products of bis(aryloxy)ethanes were characterized.
