203302-94-7

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Fluoro-phenoxy)-phenylamine is used as an intermediate in the production of various pharmaceuticals for its ability to be incorporated into the molecular structure of different drugs, enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Industry:
3-(4-Fluoro-phenoxy)-phenylamine is used as an intermediate in the production of agrochemicals for its potential to be integrated into the formulation of various agricultural products, such as pesticides and herbicides, to improve their efficacy in protecting crops.
Used in Dye and Pigment Industry:
3-(4-Fluoro-phenoxy)-phenylamine is used as a component in the manufacturing of dyes and pigments for its ability to contribute to the color properties and stability of these products, making them suitable for various applications, including textiles, plastics, and printing inks.
Used in Fine Chemicals Industry:
3-(4-Fluoro-phenoxy)-phenylamine is used in the production of other fine chemicals for its potential to be utilized in the synthesis of specialty chemicals, such as fragrances, flavorings, and other high-value compounds.

Upstream product

• 371-41-5 4-Fluorophenol 
• 591-19-5 m-Bromoaniline 
• 352-34-1 4-fluoro-1-iodobenzene 
• 591-27-5 m-Hydroxyaniline 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 50904-38-6 1-bromo-3-(4-fluorophenoxy)benzene 
• 554-84-7 meta-nitrophenol 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 907182-14-3 4-[3-(4-fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1192189-20-0 tert-butyl 4-(3-(4-fluorophenoxy)phenylcarbamoyl)-4-methylpiperidine-1-carboxylate 
• 871308-66-6 4-amino-piperidine-1-sulfonic acid [3-(4-fluoro-phenoxy)-phenyl]-amide 

Relevant academic research and scientific papers

Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives

A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channe

HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6

The present disclosure relates to compounds capable of modulating the activity of NR2F6. The compounds of the disclosure may be used in methods for the prevention and/or the treatment of diseases and disorders associated with modulating NR2F6 activity.

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

Orthogonal Cu- and Pd-based catalyst systems for the O- and N-arylation of aminophenols

O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods employing picolinic acid or CyDMEDA, trans-N,N′-dimethyl-1,2- cyclohexanediamine, respectively, as the ligand. The selective formation of N-arylated products of 3- and 4-aminophenols can be obtained with BrettPhos precatalyst, a biarylmonophosphine-based palladium catalyst. 2-Aminophenol can be selectively N-arylated with CuI, although no system for the selective O-arylation could be found. Coupling partners with diverse electronic properties and a variety of functional groups can be selectively transformed under these conditions.

4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds

Substituted 4-piperidin-1-yl-7H-pyrrolo[2,3-D]pyrimidine compounds are disclosed, as well as compositions comprising them and methods of their use for the treatment, prevention and management of various diseases and disorders.

Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity

The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted diamines. A preferred specific N,N-disubstituted diamine is the compound: