203335-99-3Relevant academic research and scientific papers
Directing Aluminum Atoms into Energetically Favorable Tetrahedral Sites in a Zeolite Framework by Using Organic Structure-Directing Agents
Muraoka, Koki,Chaikittisilp, Watcharop,Yanaba, Yutaka,Yoshikawa, Takeshi,Okubo, Tatsuya
, p. 3742 - 3746 (2018)
The Al location in zeolites can have massive influences on the zeolite properties because it directly correlates with the cationic active sites. Herein, the synthesis of IFR zeolites with controlled Al distribution at different tetrahedral sites (T sites)
Quaternary salts derived from 3-substituted quinuclidine as potential antioxidative and antimicrobial agents
Od?ak, Renata,?prung, Matilda,Soldo, Barbara,Sko?ibu?i?, Mirjana,Gudelj, Martina,Mui?, Anita,Primo?iènes, Ines
, p. 320 - 331 (2017)
Two series of novel ammonium salts containing the quinuclidine moiety were prepared in order to evaluate their antioxidative, antibacterial and antifungal potential. The synthesized homologues of 3-hydroxy (QOH) and 3-chloroquinuclidine (QCl) with the different N-benzyl substituents at the para-position (bromo, chloro or nitro group) were obtained in very good yields and characterized by IR and NMR spectroscopies and elemental analysis. All compounds were tested for antioxidative activity using the oxygen radical absorbance capacity (ORAC) assay and among tested samples, N-p-nitrobenzyl-3-hydroxyquinuclidinium bromide (QOH-4) exhibited the highest antioxidative potential (293.80 nmol (TE) mL-1), which was further investigated by the DNA nicking assay. The biological activity of selected compounds was evaluated by measuring the zone of inhibition and by determining the minimal inhibitory concentration (MIC) against three Gram-positive bacteria (B. cereus, E. faecalis and S. aureus), three Gram-negative bacteria (E. coli, P. aeruginosa and C. sakazakii) and three fungi species (C. albicans, A. Niger and P. notatum). The bioactivity assay showed that some newly synthetized quaternary quinuclidinium compounds display a comparable or even better antibacterial and antifungal activity than the reference drugs such as gentamicin (GEN), cefotaxime (CTX) and amphotericin B (AMPHB). Among the tested compounds, N-p-chlorobenzyl-3-hydroxyquinuclidinium bromide (QOH-3) exhibited a considerable antibacterial efficiency against P. aeruginosa (MIC=0.39 μg mL-1) and QOH-4 displayed a potent antifungal activity against C. albicans (MIC=1.56 μg mL-1).
